Document Detail


Cis-platinum(II) diamine dichloride causes mutation, transformation, and sister-chromatid exchanges in cultured mammalian cells.
MedLine Citation:
PMID:  440327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-tumor agent cis-platinum(II) diamine dichloride caused dose-dependent toxicity in V79 Chinese hamster cells and in secondary Syrian hamster embryo cells. Chromosome aberrations were induced and positive dose--response relationships were observed for induction of sister-chromatid exchanges and 6-thioguanine-resistant mutations in V79 cells and morphologic transformation of secondary Syrian hamster embryo cells. The findings suggest that this chemical is a potential human carcinogen.
Authors:
D Turnbull; N C Popescu; J A DiPaolo; B C Myhr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  66     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Chromosome Aberrations*
Chromosomes / drug effects*
Cisplatin / pharmacology*
Cricetinae
Crossing Over, Genetic
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Embryo, Mammalian
Mesocricetus
Mutagens*
Chemical
Reg. No./Substance:
0/Mutagens; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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