Document Detail

Cirrhosis: multiobserver analysis of hepatic MR imaging findings in a heterogeneous population.
MedLine Citation:
PMID:  8448392     Owner:  NLM     Status:  MEDLINE    
To investigate the magnetic resonance (MR) imaging findings of hepatic cirrhosis and the potential of MR imaging in differentiating cirrhosis from other hepatic abnormalities, three observers with different levels of expertise in MR imaging (specialist, experienced radiologist, and novice with special training) reviewed hepatic MR imaging examinations of 52 patients with biopsy-proved presence (n = 29) or absence (n = 23) of cirrhosis. All examinations included motion-compensated T1-weighted, T2-weighted, and flow-sensitive gradient-echo images. For all three observers, linear signal irregularity was more accurate than other findings. For the final diagnosis of cirrhosis, the specialist was most sensitive (76% at high threshold, 97% at low threshold), followed by the novice with special training (31% and 79%, respectively). Specificity was 100% for all observers at high threshold and 78%, 96%, and 87% for expert, experienced, and trained novice observers, respectively, at low threshold. Sensitivity did not vary regardless of severity of fibrosis, as determined independently by a hepatopathologist. MR imaging has the potential of offering a comprehensive noninvasive evaluation of patients with suspected cirrhosis, but considerable expertise is required at present.
D G Mitchell; K E Lovett; H W Hann; S Ehrlich; J Palazzo; R Rubin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  3     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:    1993 Mar-Apr
Date Detail:
Created Date:  1993-04-15     Completed Date:  1993-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-21     Citation Subset:  IM    
Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
False Positive Reactions
Hepatic Veins / pathology
Liver / blood supply,  pathology
Liver Cirrhosis / diagnosis*,  pathology
Magnetic Resonance Imaging*
Observer Variation
ROC Curve
Sensitivity and Specificity
Spleen / pathology
Varicose Veins / diagnosis
Vena Cava, Inferior / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Selective impairment of the synthesis of basic fibroblast growth factor binding domains of heparan s...
Next Document:  T2-weighted MR imaging of focal hepatic lesions: comparison of various RARE and fat-suppressed spin-...