| Cirrhosis of the liver: MR imaging with mangafodipir trisodium (Mn-DPDP). | |
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MedLine Citation:
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PMID: 8596867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the usefulness of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (Mn-DPDP) in magnetic resonance (MR) imaging of cirrhotic livers. MATERIALS AND METHODS: Fifty-eight patients (mean age, 58.8 years), 29 with and 29 without cirrhosis, underwent MR imaging before and after intravenous administration of 5 mumol/kg Mn-DPDP. Enhancement effects were assessed quantitatively and qualitatively. Histologic confirmation was obtained in 51 patients. RESULTS: Liver parenchyma in both patient groups enhanced significantly on T1-weighted spin-echo and gradient-recalled-echo (GRE) images (P < .01). However, cirrhotic livers enhanced significantly less than noncirrhotic livers on T1-weighted GRE images (P < .05). Fourteen cirrhotic livers had heterogeneous enhancement of parenchyma; enhancement was more prominent on GRE images. Decreased enhancement was seen in patients with confluent fibrosis (n = 5), diffuse fibrosis (n = 6), and siderotic regenerating nodules (n = 4). Increased enhancement was seen in patients with benign regenerating nodules (n = 4). CONCLUSION: Mn-DPDP is useful in patients with cirrhosis. |
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Authors:
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T Murakami; R L Baron; M P Federle; M S Peterson; J H Oliver; P L Davis; S R Confer |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 198 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-04-16 Completed Date: 1996-04-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 567-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Pittsburgh Medical Center, PA 15213-2582, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Contrast Media Edetic Acid / analogs & derivatives*, diagnostic use Female Humans Image Processing, Computer-Assisted Liver / pathology* Liver Cirrhosis / diagnosis* Liver Neoplasms / diagnosis Magnetic Resonance Imaging / methods* Male Middle Aged Pyridoxal Phosphate / analogs & derivatives*, diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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