Document Detail

Cirrhosis does not shift the circadian phase of plasma fibrinolysis.
MedLine Citation:
PMID:  12094875     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the present investigation was to study the endogenous circadian clock phase rhythm in cirrhotic patients. METHODS: The study population comprised 13 patients with cirrhosis (seven in Child-Pugh class A and six in classes B/C) and nine healthy controls. Plasma melatonin, tissue plasminogen activator antigen, and plasminogen activator inhibitor 1 antigen were measured at 4-h intervals over a 24-h period. Multiple-components rhythmometry using population mean cosinor methods were employed to analyze the findings. RESULTS: All three variables were characterized in both patients and controls by a statistically significant circadian rhythm, with similar profiles. The peak times of tissue plasminogen activator and plasminogen activator inhibitor 1 antigens were practically identical in controls and cirrhotic patients, irrespective of Child-Pugh class (calculated peak at times 6:52, 6:56, and 7:20 for the inhibitor in controls and Child-Pugh class A and classes B/C patients, respectively; p = ns), whereas the peak of melatonin was delayed in classes B/C patients (at times 2:08, 1:56, and 4:00, respectively; p < 0.05). CONCLUSION: The similar circadian phases of plasminogen activator inhibitor antigen in controls and cirrhotic patients in the present investigation indicates that the output rhythm of the internal timekeeping system is not shifted in this pathological condition.
Fabio Piscaglia; Ramon C Hermida; Sebastiano Siringo; Cristina Legnani; Giuliano Ramadori; Luigi Bolondi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  97     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-03     Completed Date:  2002-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1512-7     Citation Subset:  IM    
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
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MeSH Terms
Circadian Rhythm*
Liver Cirrhosis / blood*
Melatonin / blood
Middle Aged
Plasminogen Activator Inhibitor 1 / blood
Reference Values
Tissue Plasminogen Activator / blood
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 73-31-4/Melatonin; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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