| Circumscribed palmo-plantar hypokeratosis: a disease of desquamation? Immunohistological study of five cases and literature review. | |
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MedLine Citation:
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PMID: 20626532 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Circumscribed palmoplantar hypokeratosis (CPH) is a recently recognized, rarely reported dermatosis that shows characteristic clinicopathological features; however, its pathogenesis remains unknown. Objective The aim of this study was to get further insight into the pathogenesis of CPH. Methods An immunohistological study was performed on five cases of CPH to investigate the expression of several epidermal proliferation and differentiation proteins, with emphasis on those involved in corneocyte desquamation [including corneodesmosin, kallikrein 5 and lympho-epithelial Kazal type inhibitor (LEKTI)]. Results In three of five cases, a decreased expression of LEKTI, corneodesmosin and filaggrin was found, along with an increased expression of kallikrein 5 and keratin 6. The expression of several other antigens (including involucrin, Ki67, p63, CD138/syndecan I, EGF-R) did not present a consistently different pattern as compared with the unaffected epidermis. Conclusion The immunohistopathologic features of CPH suggest that an altered (accelerated) corneocyte desquamation process could be the main pathological mechanism underlying the development of lesions. |
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Authors:
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J Kanitakis; V Lora; B Chouvet; G Zambruno; M Haftek; M Faure |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: 25 ISSN: 1468-3083 ISO Abbreviation: J Eur Acad Dermatol Venereol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 296-301 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology. |
Affiliation:
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Department of Dermatology (Pav. R) and Laboratory of Dermatopathology (Bldg 10), Ed. Herriot Hospital, Lyon cx 03, France Istituto Dermopatico dell'Immacolata, Rome, Italy EA 4169, Ed. Herriot Hospital (Pav. R), Lyon cx 03, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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