Document Detail


Circumpolar maternal blood contaminant survey, 1994-1997 organochlorine compounds.
MedLine Citation:
PMID:  15325158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the past 20 years a number of studies have found neurological and immunological effects in the developing fetus and infants exposed to background or only slightly elevated levels of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs). To address concerns arising from possible increased human exposure in the Arctic and possible effects of POPs, all circumpolar countries agreed in 1994 to monitoring of specific human tissues for contaminants in the Arctic under the Arctic Monitoring and Assessment Program (AMAP). Mothers in eight circumpolar countries contributed blood samples that were analysed at a single laboratory for 14 PCB congeners (IUPAC No. 28, 52, 99, 105, 118, 128, 138, 153, 156, 170, 180, 183, 187) and 13 organochlorine pesticides (aldrin, beta-hexachlorocyclohexane (beta-HCH), dichlordiphenyltrichloroethane (p,p'-DDT), diphenyldichloroethylene (p,p'-DDE), dieldrin, heptachlorepoxide, hexachlorobenzene (HCB), mirex, and the chlordane derivatives alpha-chlordane, gamma-chlordane, cis-nonachlor, oxychlordane and trans-nonachlor). Inuit mothers from Greenland and Canada have significantly higher levels of oxychlordane, transnonachlor and mirex than mothers from Norway, Sweden, Iceland and Russia. Inuit mothers from Greenland also have significantly higher levels of these contaminants than Inuit mothers from Canada and Alaska. These differences among Inuit groups may represent regional dietary preferences or different contaminant deposition patterns across the Arctic. Levels of PCBs are also elevated among some arctic populations due to their consumption of marine mammals and are in the range where subtle effects on learning and the immune system have been reported. The Russian mothers who consume mainly food imported from southern Russia have elevated levels of DDT, DDE, beta-HCH and a higher proportion of lower chlorinated PCB congeners. This study has allowed an assessment of the variation of contaminants such as PCBs and various organochlorine pesticides (DDT, chlordane, etc.) in human populations around the circumpolar north.
Authors:
J C Van Oostdam; E Dewailly; A Gilman; J C Hansen; J O Odland; V Chashchin; J Berner; J Butler-Walker; B J Lagerkvist; K Olafsdottir; L Soininen; P Bjerregard; V Klopov; J P Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Science of the total environment     Volume:  330     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2004-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-70     Citation Subset:  IM    
Affiliation:
Safe Environment Program, Health Canada, PL 0801A2, Ottawa, ON K1A OL2. jay_van_oostdam@hc-sc.gc.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Arctic Regions
Data Collection
Diet*
Environmental Exposure*
Environmental Pollutants / blood*
Female
Humans
Insecticides / blood*
Polychlorinated Biphenyls / blood*
Pregnancy
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Insecticides; 0/Polychlorinated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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