| Circulatory and vestibular implications of central angiotensin mechanisms in physiological adaptation to weightlessness. | |
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MedLine Citation:
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PMID: 7334945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of an iso-renin angiotensin (AII) system within the central nervous system (CNS) led investigators to theorize a physiological and/or pathological role for the central actions of AII. Activation of central AII receptors in specific brain regions elicits antidiuretic, dipsogenic and pressor responses subsequently producing net body fluid retention. Removal of hydrostatic forces during weightlessness causes a massive translocation of body fluids to the thoraco-abdominal region; physiological adaptation to such a change is manifested as adipsia and net body fluid loss. It is suggested that these events may result from a decrease in the CNS-mediated effects of AII due to suppression of circulating AII levels. Depressed AII activity in the area postrema (AP) may also be responsible for the atypical nausea characteristic of space sickness. |
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Authors:
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R J Barrett; M F Lokhandwala |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 7 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1415-9 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Angiotensin II / blood, physiology* Animals Brain / physiology* Dogs Endorphins / physiology Humans Medulla Oblongata / physiopathology Narcotic Antagonists / therapeutic use Nausea / drug therapy, physiopathology Rats Space Flight Weightlessness* |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 0/Narcotic Antagonists; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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