Document Detail

Circulatory and vestibular implications of central angiotensin mechanisms in physiological adaptation to weightlessness.
MedLine Citation:
PMID:  7334945     Owner:  NLM     Status:  MEDLINE    
The discovery of an iso-renin angiotensin (AII) system within the central nervous system (CNS) led investigators to theorize a physiological and/or pathological role for the central actions of AII. Activation of central AII receptors in specific brain regions elicits antidiuretic, dipsogenic and pressor responses subsequently producing net body fluid retention. Removal of hydrostatic forces during weightlessness causes a massive translocation of body fluids to the thoraco-abdominal region; physiological adaptation to such a change is manifested as adipsia and net body fluid loss. It is suggested that these events may result from a decrease in the CNS-mediated effects of AII due to suppression of circulating AII levels. Depressed AII activity in the area postrema (AP) may also be responsible for the atypical nausea characteristic of space sickness.
R J Barrett; M F Lokhandwala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  7     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1415-9     Citation Subset:  IM; S    
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MeSH Terms
Adaptation, Physiological*
Angiotensin II / blood,  physiology*
Brain / physiology*
Endorphins / physiology
Medulla Oblongata / physiopathology
Narcotic Antagonists / therapeutic use
Nausea / drug therapy,  physiopathology
Space Flight
Reg. No./Substance:
0/Endorphins; 0/Narcotic Antagonists; 11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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