Document Detail

Circulatory shock in pregnant sheep. IV. Fetal and neonatal circulatory responses to hypovolemia--influence of anesthesia.
MedLine Citation:
PMID:  31092     Owner:  NLM     Status:  MEDLINE    
Hemodynamic responses to hypovolemia were investigated in unanesthetized, unstressed fetal lambs and in acute fetal and neonatal preparations. The unstressed fetus tolerated twice the amount of blood loss of the acutely studied fetus or newborn lamb and with a lesser hypotension. Hemodynamic behavior of the newborn lamb and fetus anesthetized with pentobarbital during hypovolemia was markedly different from that of the fetus studied under spinal anesthesia or chronically. Besides tolerating greater blood loss, the unstressed fetus reversed the state of hypovolemic shock rapidly as contrasted to the stressed fetus which was unable to do so even with total blood reinfusion. All animals exhibited bradycardia in response to hypovolemia. The following conclusions were drawn: (a) cardiovascular response to hypovolemia in the perinatal period depends on the initial status of the animal, (b) the fetus tolerates a greater degree of blood loss than a newborn or adult animal, and (c) anesthesia and stress of surgery modify considerably circulatory behavior during blood loss.
B Nuwayhid; D Vaughn; C R Brinkman; N S Assali
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  132     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-66     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Intravenous
Anesthesia, Obstetrical
Anesthesia, Spinal
Animals, Newborn / physiology
Blood Pressure / drug effects
Carbon Dioxide / blood
Fetus / physiology*
Heart Rate / drug effects
Hemodynamics* / drug effects
Hemoglobins / metabolism
Hydrogen-Ion Concentration
Oxygen / blood
Pentobarbital / pharmacology
Pregnancy Complications / physiopathology*
Shock / physiopathology*
Stress, Physiological / complications
Reg. No./Substance:
0/Hemoglobins; 124-38-9/Carbon Dioxide; 76-74-4/Pentobarbital; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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