Document Detail

Circulatory responses to thiopentone and tracheal intubation in patients with coronary artery disease. Effects of pretreatment with labetalol.
MedLine Citation:
PMID:  3888239     Owner:  NLM     Status:  MEDLINE    
The haemodynamic responses to induction and tracheal intubation have been studied in patients with coronary artery disease randomly assigned to a labetalol pretreatment group (n = 14) or to a placebo group (n = 16). Twelve hour before operation, treated patients received a bolus dose of labetalol 0.5 mg kg-1 followed by a constant infusion of 0.1 mg kg-1 h-1 i.v. Anaesthesia was induced with thiopentone and phenoperidine, and intubation performed following the administration of suxamethonium. At intubation, the changes in heart rate (P less than 0.01), mean arterial pressure (P less than 0.05) and rate-pressure product (P less than 0.01) were significantly smaller in the labetalol group compared with the placebo group. Labetalol pretreatment appears satisfactory and may be useful in patients with coronary artery disease who have a normal left ventricular ejection fraction.
M Fischler; C Dubois; D Brodaty; S Schlumberger; J C Melchior; D Guilmet; G Vourc'h
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  57     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-19     Completed Date:  1985-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  493-6     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General
Blood Pressure / drug effects
Cardiac Output / drug effects
Clinical Trials as Topic
Coronary Disease / physiopathology*
Double-Blind Method
Ethanolamines / therapeutic use*
Heart Rate / drug effects
Hemodynamics / drug effects*
Intubation, Intratracheal*
Labetalol / therapeutic use*
Middle Aged
Pulmonary Wedge Pressure / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Ethanolamines; 36894-69-6/Labetalol; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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