| Circulatory physiology in the developing embryo. | |
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MedLine Citation:
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PMID: 11801893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Knowledge of early developmental circulatory physiology has lagged behind advances in molecular cardiology. Cardiovascular physiology changes during embryonic development in a highly complex and carefully orchestrated manner, tightly correlated with structural development. Circulatory changes in early development include increasing heart rate, preload, and cardiac output; decreasing peripheral resistance; and increasing ventricular compliance, paralleling the increasing metabolic needs of the growing embryo. Newer techniques and the recent ability to study mammalian models of development have led to further insight into changes in myocardial and peripheral vascular physiology. The next major challenges include understanding the mechanisms regulating cardiovascular hemodynamics, normal physiologic adaptation of the growing embryo, and the physiology of abnormal cardiovascular development. |
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Authors:
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C K Phoon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current opinion in pediatrics Volume: 13 ISSN: 1040-8703 ISO Abbreviation: Curr. Opin. Pediatr. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-01-21 Completed Date: 2002-02-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9000850 Medline TA: Curr Opin Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 456-64 Citation Subset: IM |
Affiliation:
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Pediatric Cardiology Program, New York University School of Medicine, New York, New York 10016, USA. colin.phoon@med.nyu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Blood Flow Velocity Coronary Circulation / physiology* Diastole / physiology Embryo, Mammalian / blood supply*, physiology* Fetal Heart / physiology* Heart Rate / physiology Heart Valves / physiology Humans Systole / physiology Ventricular Function |
| Grant Support | |
ID/Acronym/Agency:
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K08HL04414/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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