| Circulatory pattern and duration of action of naloxone in dogs with and without opioid pretreatment. | |
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MedLine Citation:
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PMID: 495037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the circulatory pattern of naloxone reversal after high-dose fentanyl infusion in dogs. Within 1 min there was a sudden decrease in total peripheral resistance with a concomitant increase in stroke volume index. All other parameters changed back in direction of pre-fentanyl values in various degrees with peak effects in about 3-7 min. The persistency of reversal was different for individual parameters, but 20 min after injection of naloxone almost all changes induced by antagonisation of narcotic activity had returned to pre naloxone levels. In a control series with animals not pretreated with opioid, naloxone was shown to have no specific pharmacologic action of its own. |
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Authors:
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E Schweichel; D Schmidt; E Schneider; J B Brückner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 23 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-12-27 Completed Date: 1979-12-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 336-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Carbon Dioxide / blood Cardiac Output / drug effects Coronary Circulation / drug effects Dogs Female Fentanyl / administration & dosage, antagonists & inhibitors, pharmacology* Half-Life Heart Rate / drug effects Hemodynamics / drug effects* Infusions, Parenteral Male Naloxone / administration & dosage, pharmacology* Oxygen / blood Oxygen Consumption / drug effects Partial Pressure Stroke Volume / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 437-38-7/Fentanyl; 465-65-6/Naloxone; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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