Document Detail

Circulatory pattern and duration of action of naloxone in dogs with and without opioid pretreatment.
MedLine Citation:
PMID:  495037     Owner:  NLM     Status:  MEDLINE    
We investigated the circulatory pattern of naloxone reversal after high-dose fentanyl infusion in dogs. Within 1 min there was a sudden decrease in total peripheral resistance with a concomitant increase in stroke volume index. All other parameters changed back in direction of pre-fentanyl values in various degrees with peak effects in about 3-7 min. The persistency of reversal was different for individual parameters, but 20 min after injection of naloxone almost all changes induced by antagonisation of narcotic activity had returned to pre naloxone levels. In a control series with animals not pretreated with opioid, naloxone was shown to have no specific pharmacologic action of its own.
E Schweichel; D Schmidt; E Schneider; J B Brückner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  23     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  336-43     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Coronary Circulation / drug effects
Fentanyl / administration & dosage,  antagonists & inhibitors,  pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Infusions, Parenteral
Naloxone / administration & dosage,  pharmacology*
Oxygen / blood
Oxygen Consumption / drug effects
Partial Pressure
Stroke Volume / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
124-38-9/Carbon Dioxide; 437-38-7/Fentanyl; 465-65-6/Naloxone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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