Document Detail


Circulatory and metabolic effects of acute beta 1-blockade in severe pre-eclampsia.
MedLine Citation:
PMID:  43657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five mg of a beta 1-adrenoceptor antagonist (atenolol) was given i.v. to 5 women with severe pre-eclampsia in the 3rd trimester of pregnancy. There was a significant decrease of both mean systolic blood pressure, from 171 to 155 mm Hg, and mean diastolic blood pressure, from 116 to 107 mm Hg. The mean maternal heart rate decreased significantly from 90 to 74 and mean fetal heart rate significantly from 145 to 138 beats per min. There were no significant changes in the plasma levels of cyclic AMP, insulin, glucose, free fatty acids, 3-hydroxy-butyrate or glycerol.
Authors:
N O Lunell; B Persson; G Aragon; B B Fredholm; H Aström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  58     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1979  
Date Detail:
Created Date:  1980-04-17     Completed Date:  1980-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  443-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic beta-Antagonists / adverse effects*
Adult
Atenolol / adverse effects*,  therapeutic use
Blood Glucose / analysis
Blood Pressure / drug effects
Cyclic AMP / blood
Fatty Acids, Nonesterified / blood
Female
Fetal Heart / drug effects
Fetus / drug effects*
Glycerol / blood
Heart Rate / drug effects
Humans
Hydroxybutyrates / blood
Infant, Newborn
Insulin / blood
Pre-Eclampsia / drug therapy*
Pregnancy
Propanolamines / adverse effects*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Propanolamines; 11061-68-0/Insulin; 29122-68-7/Atenolol; 56-81-5/Glycerol; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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