| Circulatory function at sub-zero temperature: venous responses to catecholamines and angiotensin II in the Antarctic fish Pagothenia borchgrevinki. | |
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MedLine Citation:
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PMID: 18941758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Catecholamines increase arterial pressure by increasing cardiac output (Q) and stroke volume (V(s)), while angiotensin II (ang II) also increases vascular resistance (R(sys)) in the Antarctic fish Pagothenia borchgrevinki. Adrenaline, phenylephrine and ang II (Asn(1), Val(5)) were injected into P. borchgrevinki. Cardiovascular variables, including central venous pressure (P(cv)) and mean circulatory filling pressure (P(mcf); an index of venous capacitance), were recorded to investigate if venous vasoconstriction can explain the increased V(s) and Q and the arterial pressor response in this species. Routine P(cv) and P(mcf) were 0.11+/-0.01 and 0.18+/-0.02 kPa, respectively. All of the drugs caused moderate increases in P(cv) and P(mcf) and the responses were attenuated after alpha-adrenergic blockade with prazosin. Although dorsal aortic pressure (P(da)) also increased in response to all agonists, the mechanisms differed. Adrenaline caused sustained increases in V(s) and Q, while R(sys) only rose transiently. Ang II had a slower effect than adrenaline and increased both R (sys) and Q, while phenylephrine only increased R(sys). This study demonstrates that P(cv) is positive and controlled by an alpha-adrenergic mechanism in P. borchgrevinki. However, given the relatively small venous response to adrenaline it seems more likely that the increases in V(s) and Q from this agonist are due to direct effects on the heart. |
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Authors:
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Erik Sandblom; Michael Axelsson; William Davison |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-22 |
Journal Detail:
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Title: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Volume: 179 ISSN: 1432-136X ISO Abbreviation: J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-20 Completed Date: 2009-06-01 Revised Date: 2009-06-08 |
Medline Journal Info:
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Nlm Unique ID: 8413200 Medline TA: J Comp Physiol B Country: Germany |
Other Details:
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Languages: eng Pagination: 165-73 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of Gothenburg, Box 463, 405 30 Göteborg, Sweden. erik.sandblom@zool.gu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology* Angiotensin II / pharmacology* Animals Antarctic Regions Blood Circulation / physiology* Blood Pressure / drug effects Cardiac Output / drug effects Catecholamines / pharmacology* Cold Temperature* Perciformes / physiology* Stroke Volume / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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