Document Detail

Circulatory control in canine acrylamide neuropathy.
MedLine Citation:
PMID:  6086739     Owner:  NLM     Status:  MEDLINE    
The baroreflex regulation of arterial blood pressure and heart rate was examined in dogs with acrylamide-induced peripheral neuropathy. In anaesthetized animals the carotid sinuses were isolated from the systemic circulation and perfused. The carotid sinus and vagus nerves were kept intact. The maximum baroreflex gain (the ratio of the change in systemic pressure to a change in sinus pressure) was significantly greater in the treated animals. A step increase in carotid sinus pressure produced long periods of asystole and sustained bradycardia in the animals with neuropathy. The alterations in the baroreceptor reflex responses were consistent with dysfunction of baroreceptor fibres in the vagus.
P M Satchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  10     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-09-07     Completed Date:  1984-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  93-106     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Carotid Sinus / physiopathology*
Heart Rate
Peripheral Nervous System Diseases / chemically induced*,  physiopathology
Reflex, Abnormal / chemically induced*,  physiopathology
Vagus Nerve / physiopathology
Reg. No./Substance:
0/Acrylamides; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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