Document Detail

Circulatory changes after surfactant bolus instillation in lung-lavaged adult rabbits.
MedLine Citation:
PMID:  8979049     Owner:  NLM     Status:  MEDLINE    
Following surfactant instillation in infants treated for respiratory distress syndrome, a mean arterial blood pressure (MABP) decrease is often observed. Its etiology and pathogenesis are still unknown. In this study various circulatory parameters were recorded continuously after surfactant instillation to elucidate the role of pulmonary vascular resistance as one possible cause for the MABP drop. Seven anesthetized adult New Zealand white rabbits were artificially ventilated after tracheotomy. Arterial and right atrial pressure were recorded continuously. Pulmonary artery pressure and cardiac output were determined by means of a thermodilution catheter. After inducing surfactant deficiency by repeated saline lavages, 200 mg/kg body weight of a natural surfactant preparation was administered by tracheal bolus instillation. PaO2 increased rapidly from 8.0 +/- 1.3 kPa to 51.2 +/- 8.8 kPa (mean +/- standard deviation) within 2 min (p < .05). MABP dropped from 12.1 +/- 1.9 kPa to 8.9 +/- 2.3 kPa within 2 min (p < .05). Pulmonary artery pressure, cardiac output, and right atrial pressure did not change during the observation period of 60 min. The results suggest that a peripheral vasodilatation is the most likely cause for the drop in MABP.
M H Wagner; H Segerer; H Koch; A Scheid; M Obladen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental lung research     Volume:  22     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-76     Citation Subset:  IM    
Department of Neonatology, Virchow-Klinikum, Humboldt University, Berlin, Germany.
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MeSH Terms
Blood Pressure / drug effects
Bronchoalveolar Lavage*
Instillation, Drug
Lung / blood supply*,  drug effects*
Oxygen / metabolism
Partial Pressure
Pulmonary Circulation / drug effects*
Pulmonary Surfactants / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Pulmonary Surfactants; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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