Document Detail


Circulatory abnormalities in cirrhosis with focus on neurohumoral aspects.
MedLine Citation:
PMID:  9353862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with cirrhosis exhibit characteristic hemodynamic changes with a hyperkinetic circulation and an abnormal distribution of the blood volume and neurohumoral regulation. Their plasma and noncentral blood volumes are increased, and the central and arterial blood volume and systemic vascular resistance are decreased. A peripheral arterial vasodilatation may be of pathogenic importance to the low systemic vascular resistance as it directly correlates to the degree of central hypovolemia. It may therefore be an important element in the development of the low arterial blood pressure and hyperkinetic circulation in cirrhosis. Various vasodilators such as atrial natriurectic peptide, calcitonin gene-related peptide, adrenomedullin, and nitric oxide are among potential candidates in the arterial vasodilatation in cirrhosis. Besides enhanced sympathetic nervous activity, activation of the renin-angiotensin-aldosterone system, and elevated circulating vasopressin, endothelin-1 may also be implicated in the hemodynamic counter-regulation in cirrhosis. Recent research has focused on the assertion that the hemodynamic and neurohumoral abnormalities in cirrhosis are part of a general circulatory dysfunction influencing the course of the disease.
Authors:
S Møller; J H Henriksen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  17     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-11     Completed Date:  1997-12-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-19     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology, Hvidovre Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Blood Circulation*
Cardiovascular System / physiopathology*
Controlled Clinical Trials as Topic
Hemodynamics
Humans
Liver Cirrhosis / physiopathology*
Neuropeptides / metabolism*
Neurotransmitter Agents / metabolism*
Renin-Angiotensin System
Chemical
Reg. No./Substance:
0/Neuropeptides; 0/Neurotransmitter Agents

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