| Circulation profile of technetium-99m labeled liposome encapsulated hemoglobin in a 10% or 50% rat hypovolemic shock model. | |
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MedLine Citation:
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PMID: 7994417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The circulation kinetics and organ biodistribution of liposome encapsulated hemoglobin (LEH) was determined non-invasively in hypovolemic rats using a technetium-99m (Tc-99m) liposome labeling procedure. Rats with an indwelling catheter had either 10% or 50% of their blood volume removed and replaced with an equal volume of LEH labeled with Tc-99m (Tc-99m LEH). Mean arterial pressures and heart rates were monitored throughout the experiment. Gamma camera images were acquired during the first 90 minutes following infusion of the Tc-99m LEH and at 20 hours post-infusion. Blood capillaries were drawn at various times to monitor Tc-99m activity and the amount of LEH remaining in circulation. There were significant differences in the kinetics and biodistribution for the two groups. In the 10% group, the LEH was removed quickly from circulation with only 0.9% remaining at 20 hours, while the 50% group had 51.2% at 20 hours. The liver and spleen were the major organs responsible for LEH clearance. The 20 hour biodistribution by tissue sampling showed that the 10% group had 37.6% in the liver and 34.3% in the spleen, while the 50% group had only 18.4% in the liver and 14.6% in the spleen. |
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Authors:
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B Goins; R Klipper; J Sanders; A S Rudolph; W T Phillips |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 22 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 1994 |
Date Detail:
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Created Date: 1995-01-17 Completed Date: 1995-01-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 909-15 Citation Subset: IM |
Affiliation:
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Radiology Department, University of Texas Health Science Center, San Antonio 78284. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Blood Substitutes / administration & dosage, pharmacokinetics* Cattle Disease Models, Animal Exchange Transfusion, Whole Blood Heart Rate Hemoglobins / administration & dosage, pharmacokinetics* Liposomes Male Rats Rats, Sprague-Dawley Shock / blood, physiopathology, therapy* Technetium Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Hemoglobins; 0/Liposomes; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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