| Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. | |
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MedLine Citation:
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PMID: 18230737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of nanotubes intravenously injected into animals in vivo is currently unknown, an issue critical to potential clinical applications of these materials. Here, using the intrinsic Raman spectroscopic signatures of single-walled carbon nanotubes (SWNTs), we measured the blood circulation of intravenously injected SWNTs and detect SWNTs in various organs and tissues of mice ex vivo over a period of three months. Functionalization of SWNTs by branched polyethylene-glycol (PEG) chains was developed, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in the reticuloendothelial system (RES), and near-complete clearance from the main organs in approximately 2 months. Raman spectroscopy detected SWNT in the intestine, feces, kidney, and bladder of mice, suggesting excretion and clearance of SWNTs from mice via the biliary and renal pathways. No toxic side effect of SWNTs to mice was observed in necropsy, histology, and blood chemistry measurements. These findings pave the way to future biomedical applications of carbon nanotubes. |
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Authors:
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Zhuang Liu; Corrine Davis; Weibo Cai; Lina He; Xiaoyuan Chen; Hongjie Dai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-01-29 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 105 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-06 Completed Date: 2008-03-07 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 1410-5 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Stanford University, Stanford, CA 94305, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / analysis, pharmacokinetics*, toxicity* Blood Circulation Injections, Intravenous Materials Testing Mice Mice, Inbred Strains Nanotubes, Carbon / analysis, toxicity* Polyethylene Glycols / chemistry, pharmacokinetics, toxicity Spectrum Analysis, Raman Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Nanotubes, Carbon; 0/Polyethylene Glycols |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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