Document Detail

Circulating vitamin D metabolites and hypercalcaemia of malignancy.
MedLine Citation:
PMID:  6548074     Owner:  NLM     Status:  MEDLINE    
Plasma concentrations of 1.25 dihydroxycholecalciferol were measured in 44 patients with malignancy associated hypercalcaemia and related to other hormonal regulators of calcium metabolism. Immunoreactive PTH concentrations were suppressed in all but 2 patients and, as a group, patients with hypercalcaemia of malignancy had lower 1.25 dihydroxycholecalciferol concentrations than normocalcaemic cancer patients. 1.25 dihydroxycholecalciferol concentrations were clearly detectable in a significant proportion (43%) of hypercalcaemia cases however, suggesting that in these patients the active vitamin D metabolite may contribute to the pathogenesis and maintenance of the hypercalcaemia by stimulating bone resorption, and/or by increasing absorption of calcium from the intestine. Measurement of plasma 1.25 dihydroxycholecalciferol concentration does not provide a wholly reliable method for distinguishing the hypercalcaemia of malignancy from primary hyperparathyroidism.
S H Ralston; R A Cowan; A G Robertson; M D Gardner; I T Boyle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  106     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-10-03     Completed Date:  1984-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  556-63     Citation Subset:  IM    
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MeSH Terms
Calcifediol / blood
Calcitonin / blood
Calcitriol / blood*
Calcium / metabolism
Hypercalcemia / blood*,  etiology
Neoplasms / complications*
Parathyroid Hormone / blood
Reg. No./Substance:
0/Parathyroid Hormone; 19356-17-3/Calcifediol; 32222-06-3/Calcitriol; 7440-70-2/Calcium; 9007-12-9/Calcitonin

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