| Circulating vaspin and its relationship with insulin sensitivity, adiponectin, and liver histology in subjects with non-alcoholic steatohepatitis. | |
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MedLine Citation:
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PMID: 21770819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Non-alcoholic steatohepatitis (NASH) is closely associated with components of metabolic syndrome. Vaspin is a novel adipocytokine that may link obesity, insulin resistance (IR), and type 2 diabetes mellitus. We aimed to investigate circulating vaspin levels in subjects with NASH and also to search for the association of vaspin with IR, adiponectin, and histological findings. MATERIAL AND METHODS: A total of 50 male patients with NASH and 30 healthy male controls were enrolled. Vaspin and adiponectin were measured with ELISA method. Insulin sensitivity determined by homeostasis model assessment (HOMA-IR) index. RESULTS: Plasma vaspin levels were higher and adiponectin levels were lower in NASH group compared with controls (p < 0.01 and p < 0.001, respectively). However, in multivariate analysis adjusted for glucose and lipid parameters, and HOMA-IR indexes, the difference in vaspin concentrations was disappeared. Nonetheless, the difference regarding the adiponectin levels remained significant between groups (p = 0.03). Vaspin was negatively correlated with low-density lipoprotein cholesterol (r = -0.32, p = 0.03) in subjects with NASH. CONCLUSIONS: This study indicates that circulating vaspin levels are not altered in male subjects with NASH. These results suggest that in the absence of metabolic risk factors, vaspin per se may not be involved in the pathogenesis of NASH. |
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Authors:
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Halil Genc; Teoman Dogru; Serkan Tapan; Muammer Kara; Cemal Nuri Ercin; Fatih Aslan; Murat Kantarcioglu; Yildirim Karslioglu; Erdim Sertoglu; Mehmet Kemal Erbil; Sait Bagci |
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Publication Detail:
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Type: Journal Article Date: 2011-07-19 |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 46 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-13 Completed Date: 2012-02-27 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: England |
Other Details:
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Languages: eng Pagination: 1355-61 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Gulhane Medical School, Ankara, Turkey. zhgenc@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adult Blood Glucose Body Mass Index Cholesterol, LDL / blood Fatty Liver / blood*, pathology* Humans Insulin Resistance* Male Multivariate Analysis Serpins / blood* Waist Circumference |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Blood Glucose; 0/Cholesterol, LDL; 0/SERPINA12 protein, human; 0/Serpins |
| Comments/Corrections | |
Comment In:
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Scand J Gastroenterol. 2012 Apr;47(4):489-90
[PMID:
22182059
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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