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Circulating thrombotic and haemostatic components in patients with coronary artery disease.
MedLine Citation:
PMID:  23105879     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The study aimed to analyze the circulating levels of thrombotic and haemostatic components; tissue factor, tissue factor pathway inhibitor, tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with acute myocardial infarction at presentation (Group 1, n=49), unstable angina and Non-ST elevated MI after treatment (Group 2, n=22), stable angina (Group 3, n=18) and healthy individuals (Group 4, n=31). Significant finding was increase in tissue factor not only in Group 1 (2.0 fold, P=0.001), Group 2 (2.2 fold, P=0.015) but also in Group 3 (1.8 fold, P=0.018) as compared to controls. In Group 1 Plasminogen activator inhibitor-1 increased significantly (35.8%, P=0.02). Tissue factor pathway inhibitor and tissue plasminogen activator demonstrated increase in Group 1 of age<40 years while insignificant changes in elder patients. Increased thrombotic and decreased fibrinolytic conditions in acute myocardial infarction patients were observed. Increase TF in stable angina demonstrates procoagulant status in these patients as well.
Authors:
Kavita K Shalia; V K Shah; M R Mashru; S L Soneji; J B Vasvani; S S Payannavar; A P Walvalkar; R A Mokal; S M Mithbawkar; K V Kudalkar; A Abraham; P K Thakur
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Publication Detail:
Type:  Journal Article     Date:  2010-02-10
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  25     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  20-8     Citation Subset:  -    
Affiliation:
H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004 India.
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