Document Detail

Circulating thrombomodulin levels in familial Mediterranean fever.
MedLine Citation:
PMID:  17067436     Owner:  NLM     Status:  MEDLINE    
Increments in circulating thrombomodulin levels reflect endothelial cell injury. Thrombomodulin can also be synthesized by several inflammatory cells including monocytes, neutrophils, and thrombomodulin itself can modulate the inflammatory response. In this study, we assessed circulating thrombomodulin concentrations in patients with familial Mediterranean fever (FMF). Twenty-five patients with FMF (F/M: 14/11) (mean age: 31.1 +/- 9.7 years) and 25 healthy controls (F/M: 13/12) (mean age: 34.6 +/- 7.0 years) were involved in the study. Thrombomodulin levels were measured by commercially available enzyme-linked immunosorbant assay (ELISA) (Immunoassay of thrombomodulin Diagnostica Stago, Asnieres-Sur-Seine, France). Twenty of the patients were in attack-free period and the remaining five had been during acute FMF attacks. Thrombomodulin levels were higher in the study group (20.9 +/- 12.1 ng/ml) than healthy controls (14.1 +/- 8.4 ng/ml) (p < 0.05). Circulating thrombomodulin levels were also higher in attack-free FMF patients (22.4 +/- 12.9 ng/ml) than controls. This study disclosed for the first time significantly higher increments in the circulating levels of thrombomodulin in FMF. This observation could be a consequence of injured endothelium and/or activated inflammatory cells.
Z Ozbalkan; M A Ozturk; A M Onat; K Ureten; I C Haznedaroglu; S Kiraz; A I Ertenli; S Kirazli; M Calguneri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  24     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-27     Completed Date:  2007-04-30     Revised Date:  2007-08-07    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S95-8     Citation Subset:  IM    
Hacettepe University School of Medicine, Internal Medicine Department, Section of Rheumatology, Ankara-Turkey.
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MeSH Terms
Case-Control Studies
Familial Mediterranean Fever / blood*
Thrombomodulin / blood*,  metabolism
Reg. No./Substance:
Erratum In:
Clin Exp Rheumatol. 2007 May-Jun;25(3):507-8

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