| Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancer. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 11882474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preliminary evidence has associated testosterone and prostate-specific antigen (PSA) with breast cancer. Our objective was to determine whether a) testosterone levels in nipple aspirate fluid (NAF), serum, or breast tissue are associated with breast cancer; b) testosterone levels in serum are associated with levels in NAF; c) PSA in NAF, serum, or breast tissue is associated with breast cancer; and d) serum PSA is associated with NAF PSA levels. We obtained 342 NAF specimens from 171 women by means of a modified breast pump. Additionally, we collected 201 blood samples from 99 women and 51 tissue samples from 41 subjects who underwent surgical resection for suspected disease. Women currently using birth control pills or hormone replacement therapy were excluded from the study. Controlling for age and menopausal status, serum testosterone was significantly increased in women with breast cancer (p = 0.002). NAF and serum testosterone levels were not associated. Neither NAF nor tissue testosterone was associated with breast cancer. Controlling for menopausal status and age, NAF PSA was significantly decreased in women with breast cancer (p < 0.001). We did not find serum PSA to be associated with breast cancer, although we found an indication that, in postmenopausal women, its levels were lower in women with cancer. Serum PSA was associated with NAF PSA in postmenopausal women (p < 0.001). PSA levels in cancerous tissue were significantly lower than in benign breast specimens from subjects without cancer (p = 0.011), whereas levels of PSA in histologically benign specimens from subjects with cancer were intermediate. Our results suggest that serum testosterone is increased and NAF PSA is decreased in women with breast cancer, with PSA expression being higher in normal than in cancerous breast tissues. NAF and serum PSA levels in postmenopausal women are correlated, suggesting that as laboratory assessment of PSA becomes more sensitive, serum PSA may become useful in identifying women with breast cancer. |
| | |
Authors:
|
Edward R Sauter; David S Tichansky; Inna Chervoneva; Eleftherios P Diamandis |
Related Documents
:
|
18411784 - A case of prostatic duct adenocarcinoma: its clinical significance in comparison with t... 17922854 - Impact of prostate-specific antigen testing on the clinical and pathological outcomes a... 17012834 - The quantification of psa mrna copies in pathologically normal pelvic lymph nodes is a ... 16985974 - Prostate cancer: epidemiology and screening. 10613594 - Changes after conservative surgical treatment for early breast carcinoma: comparison of... 9209014 - Diet, nutrition and prostate cancer. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Environmental health perspectives Volume: 110 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-03-07 Completed Date: 2002-06-19 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: United States |
Other Details:
|
Languages: eng Pagination: 241-6 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Thomas Jefferson University Hospital, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA. Edward.Sauter@mail.tju.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Biopsy, Needle Breast Neoplasms / pathology* Female Humans Middle Aged Nipples Prostate-Specific Antigen / analysis* Sensitivity and Specificity Testosterone / analysis* Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological; 58-22-0/Testosterone; EC 3.4.21.77/Prostate-Specific Antigen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 3 Year: 2002 Volume: 110 Issue: 3 First Page: 241 Last Page: 246 ID: 1240763 PubMed Id: 11882474 Publisher Item Identifier: sc271_5_1835 |
| Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancer. | |
| Edward R Sauter | |
| David S Tichansky | |
| Inna Chervoneva | |
| Eleftherios P Diamandis | |
| Department of Surgery, Thomas Jefferson University Hospital, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA. Edward.Sauter@mail.tju.edu |
|
Article Categories:
|
|
Previous Document: Analysis of aggregate exposure to chlorpyrifos in the NHEXAS-Maryland investigation.
Next Document: Sexually dimorphic behavioral responses to prenatal dioxin exposure.