| Circulating tachykinins (substance P, neurokinin A, neuropeptide K) and the carcinoid flush. | |
| | |
MedLine Citation:
|
PMID: 2882598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antisera of defined regional specificity have been used to measure the concentration of substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) during a meal-induced flush in 10 patients with metastatic carcinoid tumours. Although all patients flushed, NKA-LI levels in five patients and SP-LI in six patients were not elevated relative to healthy subjects (NKA-LI, less than 3 pg/ml; SP-LI, less than 10 pg/ml) both in the fasted state and after food. In the patients with elevated basal plasma tachykinin levels, increases in NKA-LI and SP-LI after food were erratic and did not correspond to a defined digestive phase or the occurrence of the flush. Chromatographic analysis of plasma demonstrated the presence of neuropeptide K and neurokinin A, and the detection of COOH-terminal fragments of substance P is consistent with the higher levels of circulating SP-LI measured with a COOH-terminally directed antiserum compared with an NH2-terminally directed antiserum. Subcutaneous injection of the somatostatin analogue SMS 201-995 (50 micrograms) alleviated symptoms of flush in two of three patients but only partially suppressed NKA-LI and SP-LI concentrations. It is concluded that circulating tachykinins cannot be solely responsible for the meal-induced carcinoid flush. |
| | |
Authors:
|
J M Conlon; C F Deacon; G Richter; F Stöckmann; W Creutzfeldt |
Related Documents
:
|
3203698 - Incidence of post-lumbar puncture headache is independent of daily fluid intake. 17430488 - Oral graft vs. host disease in children--treatment with topical tacrolimus ointment. 23275098 - Assessment of nutrient intakes of picky-eating chinese preschoolers using a modified fo... 3411388 - Atopic dermatitis: clinical relevance of food hypersensitivity reactions. 19849798 - The role of melanocortin neuronal pathways in circadian biology: a new homeostatic outp... 19090708 - Enantioselective analysis of 2- and 3-hydroxy fatty acids in food samples. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 22 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1987 Jan |
Date Detail:
|
Created Date: 1987-05-21 Completed Date: 1987-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 97-105 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Carcinoid Tumor / blood* Female Food Humans Male Middle Aged Neurokinin A Neuropeptides / blood* Octreotide Peptides / blood* Somatostatin / analogs & derivatives, pharmacology Tachykinins* |
| Chemical | |
Reg. No./Substance:
|
0/Neuropeptides; 0/Peptides; 0/Tachykinins; 0/neuropeptide K; 0/substance P-like peptides; 51110-01-1/Somatostatin; 83150-76-9/Octreotide; 86933-74-6/Neurokinin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The immediate effect of human renal transplantation on basal and meal-stimulated levels of gastroint...
Next Document: Therapeutic strategy in arterial hypertension