Document Detail


Circulating tachykinins (substance P, neurokinin A, neuropeptide K) and the carcinoid flush.
MedLine Citation:
PMID:  2882598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antisera of defined regional specificity have been used to measure the concentration of substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) during a meal-induced flush in 10 patients with metastatic carcinoid tumours. Although all patients flushed, NKA-LI levels in five patients and SP-LI in six patients were not elevated relative to healthy subjects (NKA-LI, less than 3 pg/ml; SP-LI, less than 10 pg/ml) both in the fasted state and after food. In the patients with elevated basal plasma tachykinin levels, increases in NKA-LI and SP-LI after food were erratic and did not correspond to a defined digestive phase or the occurrence of the flush. Chromatographic analysis of plasma demonstrated the presence of neuropeptide K and neurokinin A, and the detection of COOH-terminal fragments of substance P is consistent with the higher levels of circulating SP-LI measured with a COOH-terminally directed antiserum compared with an NH2-terminally directed antiserum. Subcutaneous injection of the somatostatin analogue SMS 201-995 (50 micrograms) alleviated symptoms of flush in two of three patients but only partially suppressed NKA-LI and SP-LI concentrations. It is concluded that circulating tachykinins cannot be solely responsible for the meal-induced carcinoid flush.
Authors:
J M Conlon; C F Deacon; G Richter; F Stöckmann; W Creutzfeldt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  22     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-05-21     Completed Date:  1987-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Carcinoid Tumor / blood*
Female
Food
Humans
Male
Middle Aged
Neurokinin A
Neuropeptides / blood*
Octreotide
Peptides / blood*
Somatostatin / analogs & derivatives,  pharmacology
Tachykinins*
Chemical
Reg. No./Substance:
0/Neuropeptides; 0/Peptides; 0/Tachykinins; 0/neuropeptide K; 0/substance P-like peptides; 51110-01-1/Somatostatin; 83150-76-9/Octreotide; 86933-74-6/Neurokinin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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