Document Detail

Circulating t-PA antigen predicts major adverse coronary events in patients with stable coronary artery disease--a 13-year follow-up.
MedLine Citation:
PMID:  12888883     Owner:  NLM     Status:  MEDLINE    
Thrombus formation after rupture of an atherosclerotic plaque plays a crucial role in coronary artery disease (CAD). A decreased endogenous fibrinolytic system and prothrombotic factors are supposed to influence coronary thrombosis. It was our aim to investigate the predictive value of tissue plasminogen activator (t-PA) antigen, von Willebrand Factor, Lipoprotein (a) and anti-cardiolipin antibodies for major adverse coronary events in patients with stable CAD in a prospective cohort study of more than 10 years. We observed 141 patients with angiographically proven CAD for a median follow-up period of 13 years. t-PA antigen was the only marker predicting coronary events (logistic regression, p = 0.044) with a poor prognosis for patients in the 5th quintile with an odds ratio of 7.3 (compared to the 1st quintile). The odds ratio even increased to 10.0 for coronary events associated with the "natural course" of CAD excluding events due to restenosis. t-PA antigen had a slightly higher prognostic power (ROC curve; AUC = 0.69) than fasting glucose (AUC = 0.68) and cholesterol (AUC = 0.67). Triglycerides influenced plasma levels of t-PA antigen (regression, p < 0.001). The predictive value of t-PA antigen remained significant after adjustment for inflammation (logistic regression, p = 0.013) and extent of CAD (p = 0.045) but disappeared adjusting for insulin resistance (p = 0.12). In conclusion t-PA antigen predicted coronary events during a very long-term follow-up with a comparable prognostic power to established cardiovascular risk factors. Markers of insulin resistance influenced t-PA antigen and its predictive value.
Alexander Niessner; Senta Graf; Mariam Nikfardjam; Walter S Speidl; Renate Huber-Beckmann; Gerlinde Zorn; Johann Wojta; Kurt Huber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  90     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  344-50     Citation Subset:  IM    
Department of Cardiology, University of Vienna, Austria.
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MeSH Terms
Antibodies, Anticardiolipin / blood*
Area Under Curve
Cohort Studies
Coronary Disease / blood*,  physiopathology*
Follow-Up Studies
Lipoprotein(a) / blood
Middle Aged
Predictive Value of Tests
Prospective Studies
ROC Curve
Risk Factors
Survival Analysis
Tissue Plasminogen Activator / blood*
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Lipoprotein(a); 0/von Willebrand Factor; EC Plasminogen Activator

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