Document Detail

Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis.
MedLine Citation:
PMID:  20074734     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has been suggested that atherosclerotic mechanisms are involved in the pathogenesis of aortic valve stenosis (AVS). We hypothesised that low levels of the soluble receptor for advanced glycation end-products (sRAGE) might be associated with AVS due to its clinical and pathological associations with atherosclerosis.
METHODS: We enrolled 75 consecutive patients with severe AVS scheduled for surgical aortic valve replacement and 39 controls without AVS matched for age and gender. Besides the traditional risk factors, we evaluated plasma levels of sRAGE, C-reactive protein (CRP) and IL-6. All patients underwent transthoracic echocardiography, carotid arteries ultrasound scan and coronary angiography. The aortic and coronary calcium by multislice computed tomography was assessed in AVS patients.
RESULTS: The values of sRAGE were significantly lower (p<0.01) in AVS patients than in controls, while the CRP levels were significantly higher (p<0.05) in AVS patients than in controls. In AVS patients the sRAGE levels correlated inversely with age, cholesterol levels and coronary calcification. In all study subjects, we found an inverse correlation between circulating sRAGE and the number of echographically assessed sites of calcification (ANOVA, p<0.0001). In multivariable logistic regression analysis after adjustment for potential confounders, the sRAGE levels were significantly and independently associated with the risk of AVS (OR=0.997, 95% CI=0.994-1.000, p=0.048).
CONCLUSION: Since sRAGE could exert antiatherogenic effects by preventing inflammatory responses mediated by cell surface RAGE activation, low levels in AVS patients indicate that ligand-RAGE axis could contribute to pathogenesis of AVS.
Giuseppina Basta; Anca I Corciu; Annamaria Vianello; Serena Del Turco; Ilenia Foffa; Teresa Navarra; Dante Chiappino; Sergio Berti; Annamaria Mazzone
Related Documents :
2291724 - The clinical role of transoesophageal echocardiography.
751734 - Sudden death in severe aortic stenosis following cardiac catheterization.
923064 - Echocardiographic study of cardiac tamponade.
20684964 - The association of acute aortic dissection with helicobacter pylori virulence specific ...
17472994 - Modulation of lipoprotein plasma concentrations during long-term anti-tnf therapy in pa...
21684204 - Negative ionotropic agents for the treatment of left ventricular outflow tract obstruct...
Publication Detail:
Type:  Journal Article     Date:  2010-01-04
Journal Detail:
Title:  Atherosclerosis     Volume:  210     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  614-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
CNR, Institute of Clinical Physiology, Pisa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aortic Valve / surgery
Aortic Valve Stenosis / blood*,  surgery
C-Reactive Protein / biosynthesis
Calcinosis / blood*
Carotid Arteries / ultrasonography
Case-Control Studies
Coronary Angiography / methods
Echocardiography / methods
Gene Expression Regulation*
Glycosylation End Products, Advanced / metabolism*
Interleukin-6 / blood
Middle Aged
Prospective Studies
Tomography, X-Ray Computed / methods
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Primary subtalar arthrodesis for the treatment of comminuted intra-articular calcaneal fractures.
Next Document:  Effect of joint laxity on polyethylene wear in total knee replacement.