Document Detail


Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis.
MedLine Citation:
PMID:  20074734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: It has been suggested that atherosclerotic mechanisms are involved in the pathogenesis of aortic valve stenosis (AVS). We hypothesised that low levels of the soluble receptor for advanced glycation end-products (sRAGE) might be associated with AVS due to its clinical and pathological associations with atherosclerosis.
METHODS: We enrolled 75 consecutive patients with severe AVS scheduled for surgical aortic valve replacement and 39 controls without AVS matched for age and gender. Besides the traditional risk factors, we evaluated plasma levels of sRAGE, C-reactive protein (CRP) and IL-6. All patients underwent transthoracic echocardiography, carotid arteries ultrasound scan and coronary angiography. The aortic and coronary calcium by multislice computed tomography was assessed in AVS patients.
RESULTS: The values of sRAGE were significantly lower (p<0.01) in AVS patients than in controls, while the CRP levels were significantly higher (p<0.05) in AVS patients than in controls. In AVS patients the sRAGE levels correlated inversely with age, cholesterol levels and coronary calcification. In all study subjects, we found an inverse correlation between circulating sRAGE and the number of echographically assessed sites of calcification (ANOVA, p<0.0001). In multivariable logistic regression analysis after adjustment for potential confounders, the sRAGE levels were significantly and independently associated with the risk of AVS (OR=0.997, 95% CI=0.994-1.000, p=0.048).
CONCLUSION: Since sRAGE could exert antiatherogenic effects by preventing inflammatory responses mediated by cell surface RAGE activation, low levels in AVS patients indicate that ligand-RAGE axis could contribute to pathogenesis of AVS.
Authors:
Giuseppina Basta; Anca I Corciu; Annamaria Vianello; Serena Del Turco; Ilenia Foffa; Teresa Navarra; Dante Chiappino; Sergio Berti; Annamaria Mazzone
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Publication Detail:
Type:  Journal Article     Date:  2010-01-04
Journal Detail:
Title:  Atherosclerosis     Volume:  210     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  614-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
CNR, Institute of Clinical Physiology, Pisa, Italy. lapina@ifc.cnr.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Aortic Valve / surgery
Aortic Valve Stenosis / blood*,  surgery
C-Reactive Protein / biosynthesis
Calcinosis / blood*
Carotid Arteries / ultrasonography
Case-Control Studies
Coronary Angiography / methods
Echocardiography / methods
Female
Gene Expression Regulation*
Glycosylation End Products, Advanced / metabolism*
Humans
Interleukin-6 / blood
Male
Middle Aged
Prospective Studies
Tomography, X-Ray Computed / methods
Chemical
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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