Document Detail


Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction.
MedLine Citation:
PMID:  21966395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P<0.006 and P<0.0001, respectively). Circulating sEng levels were higher in primigravidae than multigravidae from both Cameroon and Malawi, irrespective of malarial infection status (p<0.046 and p<0.001, respectively). Peripheral parasitemia in Cameroonian women and PM in Malawian women were each associated with elevated sEng levels following correction for gestational age and gravidity (p = 0.006 and p = 0.033, respectively). Increased sEng was also associated with the delivery of LBW infants in primigravid Malawian women (p = 0.017); the association was with fetal growth restriction (p = 0.003) but not pre-term delivery (p = 0.286). Increased circulating maternal sEng levels are associated with P. falciparum infection in pregnancy and with fetal growth restriction in primigravidae with PM.
Authors:
Karlee L Silver; Andrea L Conroy; Rose G F Leke; Robert J I Leke; Philomina Gwanmesia; Malcolm E Molyneux; Diane Wallace Taylor; Diane Taylor Wallace; Stephen J Rogerson; Kevin C Kain
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-09-22
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-06-08     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e24985     Citation Subset:  IM    
Affiliation:
Sandra A. Rotman Laboratories, McLaughlin-Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD / blood*
Cameroon
Case-Control Studies
Female
Fetal Growth Retardation / blood*
Gestational Age
Humans
Malaria / blood*
Malawi
Neovascularization, Physiologic
Placenta / parasitology*
Pregnancy
Pregnancy Complications, Parasitic*
Pregnancy Outcome
Prospective Studies
Receptors, Cell Surface / blood*
Transforming Growth Factor beta / metabolism
Grant Support
ID/Acronym/Agency:
063215//Wellcome Trust; 5UO1AI43888/AI/NIAID NIH HHS; MOP-115160//Canadian Institutes of Health Research; MOP-13721//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/ENG protein, human; 0/Receptors, Cell Surface; 0/Transforming Growth Factor beta
Comments/Corrections
Erratum In:
PLoS One. 2011;6(10). doi:10.1371/annotation/e9946f72-821d-45ea-bcd4-3fa3ff89a5fe
Note: Wallace, Diane Taylor [corrected to Taylor, Diane Wallace]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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