| Circulating secretory phospholipase A2 in critical illness--the importance of the intestine. | |
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MedLine Citation:
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PMID: 16573513 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the role of secretory phospholipase A2 in the pathogenesis of multiple organ failure in the critically ill patient. DATA SOURCES: Relevant articles and published reviews on secretory phospholipase A2 in critical illness. SUMMARY OF REVIEW: Secretory phospholipase A2 (sPLA2) has an important role in inflammation and in antimicrobial defence. However, excessive activity of sPLA2 has been shown to result in tissue damage and has been implicated as a mediator of organ failure associated with critical illness. Gastrointestinal release of secretory phospholipase A2 from Paneth cells increases during intestinal ischaemia and may be an important factor in the pathogenesis of the multiple organ dysfunction syndrome. In experimental models, specific PLA2 inhibitors reduce organ failure associated with sPLA infusion and may play an important role in reducing organ failure in the management of the critically ill patient. CONCLUSIONS: Intestinal ischaemia may play an important role in the pathogenesis of the multiple organ dysfunction syndrome in the critically ill patient. In patients with sepsis, specific PLA2 inhibitors have the potential to reduce organ failure and improve morbidity and mortality. |
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Authors:
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C Corke; K Glenister; T Watson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Volume: 3 ISSN: 1441-2772 ISO Abbreviation: Crit Care Resusc Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2006-03-31 Completed Date: 2006-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888170 Medline TA: Crit Care Resusc Country: Australia |
Other Details:
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Languages: eng Pagination: 244-9 Citation Subset: - |
Affiliation:
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Intensive Care Unit, The Geelong Hospital, and Deakin University, Geelong, Victoria. charliec@barwonhealth.org.au |
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Comment In:
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Crit Care Resusc. 2001 Dec;3(4):221-2
[PMID:
16573506
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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