| Circulating sTWEAK improves the prediction of coronary artery disease. | |
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MedLine Citation:
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PMID: 19505454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. DESIGN AND METHODS: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. RESULTS: Serum sTWEAK concentrations were significantly lower in the patients (534.5+/-110.9 microg/L) than in the controls (688.1+/-150.0 microg/L, p<0.001), even after adjusting for different confounders (p<0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p=0.011-0.035). CONCLUSIONS: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers. |
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Authors:
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Zorana Jeli??-Ivanovi??; Nada Bujisi??; Slavica Spasi??; Natasa Bogavac-Stanojevi??; Vesna Spasojevi??-Kalimanovska; Jelena Kotur-Stevuljevi?? |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-06 |
Journal Detail:
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Title: Clinical biochemistry Volume: 42 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1381-6 Citation Subset: IM |
Affiliation:
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Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. zorana.jelic@pharmacy.bg.ac.rs |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Biological Markers / blood Coronary Artery Disease / blood, diagnosis* Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Humans Logistic Models Male Middle Aged Predictive Value of Tests ROC Curve Tumor Necrosis Factors / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/TNFSF12 protein, human; 0/Tumor Necrosis Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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