Document Detail


Circulating sTWEAK improves the prediction of coronary artery disease.
MedLine Citation:
PMID:  19505454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. DESIGN AND METHODS: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. RESULTS: Serum sTWEAK concentrations were significantly lower in the patients (534.5+/-110.9 microg/L) than in the controls (688.1+/-150.0 microg/L, p<0.001), even after adjusting for different confounders (p<0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p=0.011-0.035). CONCLUSIONS: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.
Authors:
Zorana Jeli??-Ivanovi??; Nada Bujisi??; Slavica Spasi??; Natasa Bogavac-Stanojevi??; Vesna Spasojevi??-Kalimanovska; Jelena Kotur-Stevuljevi??
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-06
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1381-6     Citation Subset:  IM    
Affiliation:
Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. zorana.jelic@pharmacy.bg.ac.rs
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Biological Markers / blood
Coronary Artery Disease / blood,  diagnosis*
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Logistic Models
Male
Middle Aged
Predictive Value of Tests
ROC Curve
Tumor Necrosis Factors / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/TNFSF12 protein, human; 0/Tumor Necrosis Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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