Document Detail

Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults.
MedLine Citation:
PMID:  23292315     Owner:  NLM     Status:  Publisher    
The purpose of this study was to identify circulating cytokines, skeletal muscle strength, and peak power output in young adults with contrasting serum 25-hydroxyvitamin D (25(OH)D) concentrations. Serum 25(OH)D, inflammatory cytokines, muscle strength, and peak power output were, therefore, measured in young adults (25-42 years). Data were collected during the winter to avoid the seasonal influence on serum 25(OH)D. After serum 25(OH)D concentration measurements, subjects were separated into one of two groups: (1) vitamin D insufficient [serum 25(OH)D ≤32 ng/mL, n = 14], or (2) vitamin D sufficient [serum 25(OH)D >32 ng/mL, n = 14]. Following group allocation, serum 25(OH)D concentrations were significantly (p < 0.05) lower and pro-inflammatory cytokines [interleukin (IL)-2, IL-1β, tumor necrosis factor-α, and interferon-γ] were significantly (all p < 0.05) greater in vitamin D insufficient adults. An anti-inflammatory cytokine (i.e., IL-10; p > 0.05), peak isometric forces (p > 0.05), and peak power outputs (p > 0.05) were not significantly different between vitamin D groups. However, peak power outputs correlated with serum 25(OH)D concentrations in vitamin D insufficient (r = 0.55, p < 0.05) but not in vitamin D sufficient adults (r = -0.27, p = 0.36). Based on these data, we conclude that vitamin D insufficiency, in part, could result in pro-inflammatory stress without altering muscular strength or function in young adults. Future research investigating the causality of the correlation between low-serum 25(OH)D and peak power output in young adults is required.
Tyler Barker; Thomas B Martins; Harry R Hill; Carl R Kjeldsberg; Brian M Dixon; Erik D Schneider; Vanessa T Henriksen; Lindell K Weaver
Related Documents :
23292315 - Circulating pro-inflammatory cytokines are elevated and peak power output correlates wi...
24815335 - Impact of urine concentration adjustment method on associations between urine metals an...
23245065 - 231 effect of different equine chorionic gonadotropin concentrations on in vitro-produc...
19388825 - Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative s...
3101755 - Thyrotropin, prolactin, and growth hormone responses to thyrotropin-releasing hormone i...
22105055 - Characterisation of the differences in strength and power between different levels of c...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-6
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Orthopedic Specialty Hospital, 5848 S. Fashion Blvd, Murray, UT, 84107, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The oncolytic herpes simplex virus vector G47? effectively targets breast cancer stem cells.
Next Document:  Trace Metals in Fleece Wool and Correlations with Yellowness.