Document Detail

Circulating plasma volume and renal function.
MedLine Citation:
PMID:  1188915     Owner:  NLM     Status:  MEDLINE    
The relationships of circulating plasma volume (PV) to effective renal plasma flow and glomerular filtration rate (GFR) were investigated in reference to their interrelated changes induced by upright posture in normal subjects and patients with chronic glomerulonephritis. The following relation was obtained: (percentage change in GFR) = k(percentage change in PV). The values of k were 3.4 for the normal and 3.1 for the patients. There was no statistically significant difference between the two. On account of the above relation the recumbent level of glomerular filtration rate (GFR)r was derived from the recumbent level of circulating plasma volume (PV)r as follows: (GFR)r = Kp [(PV)r]k, where Kp is a constant. On the other hand, the decreases (percentage) in effective renal plasma flow were biphasically related to those in PV. Mean arterial pressure rose in upright posture in many cases, but its changes (percentage) showed no correlation with the changes (percentage) in GFR. These results suggest that in a small decrease in PV, GFR does not decrease with the fall in mean arterial pressure, but with the power function of PV. The possible mechanisms of these changes in renal function are examined with special reference to the structure of renal arterial system.
Y Sasaki; T Furuyama; R Shioji; H Ueda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  116     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1976-01-30     Completed Date:  1976-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  299-315     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Glomerular Filtration Rate*
Glomerulonephritis / physiopathology
Kidney / blood supply*
Kidney Failure, Chronic / physiopathology
Plasma Volume*

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