Document Detail


Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community.
MedLine Citation:
PMID:  21430561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Clinical trials using cholesteryl ester transfer protein (CETP) inhibitors to raise high-density lipoprotein cholesterol (HDL-C) concentrations reported an 'off-target' blood pressure (BP) raising effect. We evaluated the relations of baseline plasma CETP activity and longitudinal BP change.
METHODS AND RESULTS: One thousand, three hundred and seven Framingham Study participants free of cardiovascular disease attending consecutive examinations 4 years apart (mean age 48 years) had baseline plasma CETP activity related to change in BP over the 4-year interval, adjusting for standard risk factors. Systolic BP increased [median +2 mmHg, 95% confidence interval (CI) -16,+23 mmHg], whereas diastolic BP decreased (median -3 mmHg, 95% CI -15,+11 mmHg). Plasma CETP activity was not related to change in diastolic BP, but was inversely related to change in systolic BP that was borderline significant (P=0.09). On multivariable analyses, plasma CETP activity was inversely related to change in pulse pressure (PP; beta per SD increment= -0.71 mmHg, P=0.005). When dichotomized at the median, plasma CETP activity above the median was associated with a 1 mmHg lower PP on follow-up (P=0.045).
CONCLUSION: Decreasing plasma CETP activity was modestly related to increasing PP on follow-up in our community-based sample, suggesting that inhibition of intrinsic CETP activity itself is likely associated with minimal changes in BP.
Authors:
Justin P Zachariah; Michael J Pencina; Asya Lyass; Guneet Kaur; Ralph B D'Agostino; Jose M Ordovas; Ramachandran S Vasan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of hypertension     Volume:  29     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-08     Completed Date:  2011-07-29     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  863-8     Citation Subset:  IM    
Copyright Information:
© 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Cholesterol Ester Transfer Proteins / blood*
Female
Humans
Male
Middle Aged
Multivariate Analysis
Grant Support
ID/Acronym/Agency:
N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; T32 HL007572/HL/NHLBI NIH HHS; T32 HL007572/HL/NHLBI NIH HHS; T32 HL007572-28/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Ester Transfer Proteins
Comments/Corrections

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