Document Detail


Circulating p53 and cytochrome c levels in acute myocardial infarction patients.
MedLine Citation:
PMID:  19551350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Apoptosis causes myocardiocyte loss during and after myocardial infarction. Therapeutic approaches designed to arrest apoptosis would be a significant new development in the recovery of acute myocardial infarction (AMI). In order to examine apoptotic markers in the circulation, serum levels of p53 and cytochrome c were assessed in patients with AMI. METHODS: Blood samples were taken on admission (before initiation of therapy) and on the 3rd and 7th days of hospitalization. Serum levels of p53 and cytochrome c were measured by enzyme-linked immunassay. RESULTS: The serum level of p53 was higher in AMI patients on admission compared to the control group. A time-dependent decrease was observed in the serum level of p53, but there was no significant change in the serum level of cytochrome c during therapy. CONCLUSIONS: p53, but not cytochrome c, appears to have potential as a biomarker for reporting on apoptosis following myocardial infarction.
Authors:
Yildiz Dincer; Solen Himmetoglu; Evin Bozcali; Vural Ali Vural; Tulay Akcay
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-24
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  29     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. stare63@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Apoptosis*
Biological Markers / blood
Cytochromes c / blood*
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood*
Tumor Suppressor Protein p53 / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Tumor Suppressor Protein p53; 9007-43-6/Cytochromes c

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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