| Circulating p53 and cytochrome c levels in acute myocardial infarction patients. | |
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MedLine Citation:
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PMID: 19551350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Apoptosis causes myocardiocyte loss during and after myocardial infarction. Therapeutic approaches designed to arrest apoptosis would be a significant new development in the recovery of acute myocardial infarction (AMI). In order to examine apoptotic markers in the circulation, serum levels of p53 and cytochrome c were assessed in patients with AMI. METHODS: Blood samples were taken on admission (before initiation of therapy) and on the 3rd and 7th days of hospitalization. Serum levels of p53 and cytochrome c were measured by enzyme-linked immunassay. RESULTS: The serum level of p53 was higher in AMI patients on admission compared to the control group. A time-dependent decrease was observed in the serum level of p53, but there was no significant change in the serum level of cytochrome c during therapy. CONCLUSIONS: p53, but not cytochrome c, appears to have potential as a biomarker for reporting on apoptosis following myocardial infarction. |
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Authors:
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Yildiz Dincer; Solen Himmetoglu; Evin Bozcali; Vural Ali Vural; Tulay Akcay |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-24 |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 29 ISSN: 1573-742X ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-24 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 41-5 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. stare63@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apoptosis* Biological Markers / blood Cytochromes c / blood* Female Humans Male Middle Aged Myocardial Infarction / blood* Tumor Suppressor Protein p53 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tumor Suppressor Protein p53; 9007-43-6/Cytochromes c |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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