| Circulating osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in polycystic ovary syndrome: relationships to insulin resistance and endothelial dysfunction. | |
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MedLine Citation:
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PMID: 20974706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: There is plenty of evidence that osteoprotegerin (OPG) is linked to subclinical vascular damage and predicts cardiovascular disease in high-risk populations. Our aim is to investigate the relationships of OPG/free soluble receptor activator of nuclear factor κB ligand (sRANKL) to insulin resistance, brachial artery flow-mediated vasodilation (FMD), and the carotid artery intima-media thickness (CIMT) in polycystic ovary syndrome (PCOS), a disorder characterized by hyperandrogenism, impaired glucose control, and endothelial injury. DESIGN: A cross-sectional, observational study. METHODS: Hormonal and metabolic profiles, FMD, CIMT, serum OPG, and ampli-sRANKL were assessed in 64 young PCOS patients and 20 controls of similar age. Body composition was measured by dual energy X-ray absorptiometry. RESULTS: OPG was significantly lower in PCOS and related negatively to free testosterone and positively to estradiol (E(2)) levels. In multivariate analysis, OPG but not ampli-sRANKL correlated positively to fasting insulin, insulin sensitivity indices, and FMD. Neither OPG nor ampli-sRANKL was associated with CIMT. Significantly lower adjusted FMD values were demonstrated in women in the upper OPG quartile group (>2.65 pmol/l) compared with all other quartile groups together (P=0.012). In PCOS, multiple regression analysis retained E(2)/sex hormone-binding globulin ratio, fat mass, and homeostasis model assessment of insulin resistance as independent predictors of OPG. CONCLUSIONS: In PCOS, circulating OPG is related to both endothelial dysfunction and insulin resistance, independent of obesity and androgen excess, suggesting OPG as a useful biomarker of these effects. Further studies are needed to evaluate OPG in relation to cardiovascular events and cardiovascular mortality in PCOS. |
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Authors:
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Carmen Emanuela Pepene; Ioana Rada Ilie; Ioan Marian; Ileana Duncea |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-25 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 164 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 61-8 Citation Subset: IM |
Affiliation:
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Departments of Endocrinology Internal Medicine-Cardiology, University of Medicine and Pharmacy Cluj-Napoca, 3-5 Louis Pasteur, 400349 Cluj-Napoca, Romania. c_e_georgescu@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Flow Velocity Body Composition Brachial Artery / physiopathology Carotid Arteries / pathology Cross-Sectional Studies Endothelium, Vascular / physiopathology Estradiol / blood Female Humans Insulin / blood Insulin Resistance* Osteoprotegerin / blood* Polycystic Ovary Syndrome / blood*, physiopathology Prospective Studies RANK Ligand / blood Receptor Activator of Nuclear Factor-kappa B / blood* Regression Analysis Sex Hormone-Binding Globulin / metabolism Testosterone / blood Tunica Intima / pathology Tunica Media / pathology Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Osteoprotegerin; 0/RANK Ligand; 0/Receptor Activator of Nuclear Factor-kappa B; 0/Sex Hormone-Binding Globulin; 11061-68-0/Insulin; 50-28-2/Estradiol; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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