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Circulating obestatin is increased in patients with cardiorenal syndrome and positively correlated with vasopressin.
MedLine Citation:
PMID:  23017530     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopresin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndome (CRS). Plasma AVP and obestatin concentration was measured in 34 patients with type II CRS. The data were compared to that in 31 patients with chronic kidney disease (CKD), 41 patients with chronic heart failure (CHF) and 30 healthy subjects. Obestatin was significantly higher in the patients with CRS (355.8±85.1pg/ml) than that in the healthy controls (212.3 ±37.9pg/ml, P<0.01), the patients with CKD (246.7±34.3pg/ml, P<0.01) and the patients with CHF (258.4±112.1pg/ml, P<0.01). AVP was also significantly higher in the patients with CRS (65.1±36.0pg/ml) than that in the healthy controls (38.5±20.1pg/ml, P<0.01), the patients with CKD (50.4±24.8pg/ml, P<0.01) and the patients with CHF (54.6±16.3pg/ml, P<0.01). Plasma concentration of obestatin was positively correlated with AVP plasma concentration in the overall analysis that included subjects from all disease categories (r=0.219, P<0.05), but not within the CRS group. Plasma obestatin and vasopressin were elevated in patients with CRS. Plasma obestatin concentration seemed to be positively correlated with plasma AVP.
Authors:
Jian-Bo Shi; Zhi-Fu Guo; Xing Zheng; Zhi-Bin Wang; Yuan-Ji Ma
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  Peptides     Volume:  -     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University. Electronic address: stevenshi12@126.com.
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