| Circulating nucleic acids in cancer and pregnancy. | |
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MedLine Citation:
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PMID: 20146940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circulating nucleic acids are present in the blood of humans and other vertebrates. During the last 10 years researchers actively studied cell-free nucleic acids present in plasma or serum with great expectations of their use as potential biomarkers for cancer and other pathologic conditions. In the present manuscript the main findings related to the principal characteristics of circulating nucleic acids, the hypothesis on their origin and some methodological considerations on sample collection and extraction as well as on some innovative assay methods have been summarized. Recent reports on the importance of circulating nucleic acids in the intercellular exchange of genetic information between eukaryotic cells have been reviewed. |
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Authors:
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Pamela Pinzani; Francesca Salvianti; Mario Pazzagli; Claudio Orlando |
Publication Detail:
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Type: Journal Article; Review Date: 2010-02-08 |
Journal Detail:
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Title: Methods (San Diego, Calif.) Volume: 50 ISSN: 1095-9130 ISO Abbreviation: Methods Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426302 Medline TA: Methods Country: United States |
Other Details:
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Languages: eng Pagination: 302-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Inc. |
Affiliation:
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Department of Clinical Physiopathology, University of Florence and Istituto Toscano Tumori, Viale Pieraccini 6, 50139 Florence, Italy. ppinzani@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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genetics Biological Markers DNA / isolation & purification DNA, Neoplasm / blood, isolation & purification Female Humans Neoplasms / blood* Nucleic Acids / blood* Pregnancy / blood* RNA / isolation & purification RNA, Neoplasm / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/DNA, Neoplasm; 0/Nucleic Acids; 0/RNA, Neoplasm; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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