| Circulating nucleic acids as a new diagnostic tool. | |
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MedLine Citation:
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PMID: 20186496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of circulating nucleic acids in the 1940s opened up new possibilities for the non-invasive detection, monitoring and screening of various human disorders. Several tumour markers that enable early cancer detection or tumour behaviour prediction have been detected in the plasma of cancer patients. Maternal plasma analysis can be used to detect certain fetal abnormalities, with the quantification of cell-free nucleic acids used to screen for several pregnancy-associated disorders. Some other applications are in transplant monitoring and graft rejection assessment, and in certain medical emergencies such as trauma and burn severity stratification. Many studies have yielded promising results in this field, but the techniques have yet to be applied in routine clinical practice. Large-scale studies using similar technologies and a broad spectrum of patients are still needed to verify the results of the various studies. |
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Authors:
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Marketa Urbanova; Jan Plzak; Hynek Strnad; Jan Betka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-25 |
Journal Detail:
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Title: Cellular & molecular biology letters Volume: 15 ISSN: 1689-1392 ISO Abbreviation: Cell. Mol. Biol. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-03-25 Completed Date: 2010-07-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607427 Medline TA: Cell Mol Biol Lett Country: Poland |
Other Details:
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Languages: eng Pagination: 242-59 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology and Head and Neck Surgery, Institute of Postgraduate Medicine, Charles University, Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Humans Nucleic Acids / blood*, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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