Document Detail

Circulating neutrophils from patients with ulcerative colitis have a normal respiratory burst.
MedLine Citation:
PMID:  8595936     Owner:  NLM     Status:  MEDLINE    
The hallmark of ulcerative colitis is a diffuse infiltration of neutrophils from the circulation into the colonic mucosa. The underlying mechanism for neutrophil tissue infiltration is unknown. One possible hypothesis is abnormal circulating neutrophils. This hypothesis has been previously tested with conflicting results. The aim of our study was to re-evaluate circulating neutrophil function in the absence of several possible confounding factors. To this end, we measured the respiratory burst of circulating neutrophils in response to two different stimuli by chemiluminescence in patients with active and inactive ulcerative colitis being off all medications. Our results show no significant difference between ulcerative colitis patients and controls in peak chemiluminescence, area-under-the-curve and time to peak comparisons. However, 27% of patients with active ulcerative colitis had an abnormally elevated chemiluminescence to stimuli. In addition, no correlations were seen between disease activity and peak chemiluminescence. Thus circulating neutrophils in the majority of patients with ulcerative colitis do not appear to be either "primed" or hyperactive. This may suggest the presence of local colonic factors that lead to neutrophil tissue infiltration and activation.
J M Haydek; A Keshavarzian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Inflammation     Volume:  19     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-04-16     Completed Date:  1996-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  701-15     Citation Subset:  IM    
Department of Medicine (Digestive Disease and Nutrition) and Pharmacology, Loyola University Medical Center, Maywood, Illinois, USA.
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MeSH Terms
Blood Cells / drug effects,  metabolism*
Chemiluminescent Measurements
Colitis, Ulcerative / blood*,  pathology,  physiopathology
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / drug effects,  metabolism*
Reference Values
Respiratory Burst*
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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