| Circulating microparticles in normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 18192006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular particles may be larger shed microparticles (>or=100 nm, MPs) that are the products of cell activation or necrosis. There are also smaller endocytic nanoparticles (<100 nm), called exosomes, which are internal vesicles of late endosomes or multivesicular bodies and are released into the extracellular milieu upon fusion of the multivesicular body with the cell surface. Both MPs and exosomes can be detected in the circulations of non-pregnant and pregnant women. In the former MPs are increased in conditions associated with systemic inflammation such as sepsis or metabolic syndrome. During normal pregnancy MPs are increased and they increase further with pre-eclampsia. They include not only MPs derived from platelets, endothelium and various leukocytes but also syncytiotrophoblast derived MPs (often called STBMs). STBMs interact with both immune and endothelial cells and may contribute to the systemic inflammation of both normal and pre-eclamptic pregnancies. However inhibitory activity has also been ascribed to trophoblast derived exosomes. In vitro, they down-regulate T cell activity, a T cell change that has been repeatedly observed, ex vivo, during normal pregnancy. |
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Authors:
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C W G Redman; I L Sargent |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-01-14 |
Journal Detail:
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Title: Placenta Volume: 29 Suppl A ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-14 Completed Date: 2008-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: S73-7 Citation Subset: IM |
Affiliation:
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Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. christopher.Redman@obs-gyn.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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ultrastructure Cytoplasmic Vesicles / pathology* Endothelial Cells / ultrastructure Female Humans Inflammation / blood, immunology, pathology Leukocytes / ultrastructure Pre-Eclampsia / blood, immunology, pathology* Pregnancy Trophoblasts / pathology*, ultrastructure* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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