| Circulating microRNAs as potential biomarkers for smoking-related interstitial fibrosis. | |
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MedLine Citation:
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PMID: 22512273 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Numerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smoking-induced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR-30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease. |
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Authors:
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Yuchuan Huang; Ya Dai; Jie Zhang; Changguo Wang; Dongliang Li; Jingqiu Cheng; Yanrong Lu; Kuoyan Ma; Lanlan Tan; Fang Xue; Bo Qin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-18 |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: - ISSN: 1366-5804 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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West China Hospital, Sichuan University , Chengdu , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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