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Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies.
MedLine Citation:
PMID:  22187671     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Until recently, the molecular pathogenesis of pre-eclampsia remained largely unknown. Reports have shown that circulating microRNAs are promising novel biomarkers for cancer, pregnancy, tissue injury and other conditions. The objective of present study was to identify differentially expressed microRNAs in plasma from severe pre-eclamptic pregnancies compared with plasma from normal pregnancies. By mature microRNA microarray analysis, 15 microRNAs, including 13 up-regulated and 2 down-regulated microRNAs, were screened to be differentially expressed in plasma from women with severe pre-eclampsia. Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis. Gene ontology and pathway enrichment analysis revealed that these microRNAs were involved in specific biological process categories (including regulation of metabolic processes, regulation of transcription, and cell cycle) and signaling pathways (including the mitogen-activated protein kinase signaling pathway, the transforming growth factor-beta signaling pathway, and pathways in cancer metastasis). This study presents, for the first time, the differential expression profile of circulating microRNAs in severe pre-eclampsia patients. The seven elevated circulating microRNAs may play critical roles in the pathogenesis of severe pre-eclampsia, and one or more of them may become potential markers for diagnosing severe pre-eclampsia.
Authors:
Liang Wu; Honghui Zhou; Haiyan Lin; Jianguo Qi; Cheng Zhu; Zhiying Gao; Hongmei Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-20
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  -     ISSN:  1741-7899     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
L Wu, the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chiense Academy of Sciences, Beijing, China.
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