Document Detail


Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study.
MedLine Citation:
PMID:  20153853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This prospective study was established to determine the impact of maternal circulating androgen levels during normal pregnancy on ovarian function, as determined by early follicular phase antimüllerian hormone (AMH) levels, inhibin B levels, and antral follicle count (AFC) in 244 female offspring in adolescence. Maternal circulating total testosterone levels at 18 weeks' gestation were statistically significantly correlated with early follicular-phase circulating AMH levels in female adolescent offspring, but no other statistically significant correlations were determined among the maternal androgens at 18 or 34 weeks of gestation and the markers of adolescent ovarian function.
Authors:
Roger Hart; Deborah M Sloboda; Dorota A Doherty; Robert J Norman; Helen C Atkinson; John P Newnham; Jan E Dickinson; Martha Hickey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-13
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1544-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society for Reproductive Medicine. All rights reserved.
Affiliation:
School of Women's and Infants' Health, University of Western Australia, and Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia. roger.hart@uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Mullerian Hormone / blood*
Cohort Studies
Female
Gestational Age
Humans
Maternal-Fetal Exchange / physiology
Mothers
Polycystic Ovary Syndrome / blood*,  diagnosis*
Pregnancy
Pregnancy Trimester, Second / blood*
Prenatal Exposure Delayed Effects / blood*
Prognosis
Prospective Studies
Testosterone / blood*
Chemical
Reg. No./Substance:
58-22-0/Testosterone; 80497-65-0/Anti-Mullerian Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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