Document Detail

Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia.
MedLine Citation:
PMID:  9853769     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether circulating markers of oxidative stress are elevated in pre-eclampsia when appropriate precautions are taken to prevent in vitro oxidation DESIGN: A prospective study. SETTING: Nuffield Department of Obstetrics and Gynaecology, Oxford and The William Harvey Institute, London. SAMPLE: Three groups of women: those with pre-eclampsia (n = 19), control pregnant women (n = 19) matched for gestation, age and parity and a group of non pregnant individuals of reproductive age (n = 7). METHODS: Citrated plasma was stored at -80 degrees C with 20 micromol beta hydroxytoluene to prevent auto-oxidation. Plasma samples were assayed for levels of 8 epi-prostaglandin F2alpha, lipid hydroperoxides, malondialdehyde and also the lipid soluble antioxidant vitamin E. RESULTS: There were no differences in 8 epi-prostaglandin F2alpha, lipid peroxide or malondialdehyde levels between the groups of women with pre-eclampsia and those acting as pregnant controls. However, lipid hydroperoxides and malondialdehyde were significantly raised in both pre-eclampsia and normal pregnancy, compared with nonpregnant women. Vitamin E levels were similar in women with pre-eclampsia and those with a normal pregnancy, but in both groups levels were significantly higher than in nonpregnant women. CONCLUSION: Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia.
J M Morris; N K Gopaul; M J Endresen; M Knight; E A Linton; S Dhir; E E Anggård; C W Redman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  105     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-12     Completed Date:  1999-01-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1195-9     Citation Subset:  AIM; IM    
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, UK.
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MeSH Terms
Biological Markers / blood
Dinoprost / analogs & derivatives*,  analysis
Lipid Peroxides / analysis
Malondialdehyde / analysis
Oxidative Stress / physiology*
Pre-Eclampsia / blood*
Pregnancy / blood*
Pregnancy Complications, Cardiovascular / blood
Prospective Studies
Vitamin E / analysis
Reg. No./Substance:
0/Biological Markers; 0/Lipid Peroxides; 1406-18-4/Vitamin E; 27415-26-5/8-epi-prostaglandin F2alpha; 542-78-9/Malondialdehyde; 551-11-1/Dinoprost
Comment In:
Br J Obstet Gynaecol. 1999 Jul;106(7):751   [PMID:  10428540 ]
Br J Obstet Gynaecol. 1999 Nov;106(11):1232   [PMID:  10549981 ]

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