Document Detail


Circulating lipoprotein(a) concentrations and abdominal aortic aneurysm presence.
MedLine Citation:
PMID:  19564206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To summarize the present evidence for an association between circulating lipoprotein(a) [Lp(a)] and abdominal aortic aneurysm (AAA) presence. MEDLINE database was searched to identify all case-control studies that compared circulating Lp(a) concentrations between patients with AAA and subjects without AAA. For each study, data regarding Lp(a) concentrations in both the AAA and control groups were used to generate standardized mean differences (SMDs) and 95% confidence intervals (CIs). Study-specific estimates were combined using inverse variance-weighted average of logarithmic SMDs in both fixed- and random-effects models. Our search identified five case-control studies. In total, our meta-analysis included data on 982 cases with AAA and 1296 controls without AAA. Pooled analysis of the five studies demonstrated significantly higher Lp(a) concentrations in the AAA group than those in the control group in random-effect models (SMD, 0.26; 95% CI, 0.08-0.44; P=0.005). There was significant study heterogeneity of results (P=0.03) but no evidence of significant publication bias (P=0.3272). We found that circulating Lp(a) concentrations are likely higher in cases with AAA than in controls without AAA. Higher circulating Lp(a) concentrations may be associated with AAA presence.
Authors:
Hisato Takagi; Hideaki Manabe; Norikazu Kawai; Shin-Nosuke Goto; Takuya Umemoto
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2009-06-29
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  9     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Shizuoka Medical Center, Sunto-gun, Shizuoka 411-8611, Japan. kfgth973@ybb.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal / blood*
Biological Markers / blood
Evidence-Based Medicine
Female
Humans
Lipoprotein(a) / blood*
Male
Middle Aged
Publication Bias
Up-Regulation
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipoprotein(a)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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