| Circulating levels of urokinase-type plasminogen activator (uPA) and its soluble receptor (suPAR) in patients with atopic eczema/dermatitis syndrome. | |
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MedLine Citation:
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PMID: 16858643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence has indicated that different immune and inflammatory processes may be accompanied by up-regulation of the uPA/uPAR system. Moreover, it has been suggested that the fibrinolytic system participates actively in immune-mediated skin disorders, including atopic eczema/dermatitis syndrome (AEDS). To study a possible role of such uPA/uPAR system in AEDS, we investigated circulating levels of uPA and suPAR in patients at different clinical stages of AEDS. Levels of u-PA and suPAR were measured by enzyme-linked immunoassay in plasma from 13 patients (five females and eight males; median age 27 years) with moderate AEDS, eight patients (three females and five males; median age 25.5 years) with severe AEDS, and 18 age- and sex-matched healthy subjects. Plasma levels of uPA and suPAR in AEDS patients did not differ significantly when compared with those in healthy subjects. Moreover, we failed to observe any significant differences in levels of these components between patients with moderate and severe AEDS and the controls. It seems that plasma levels of uPA and suPAR are similar in patients at the different stages of AEDS and the healthy subjects. Moreover, these data suggest that the release of uPA and its soluble receptor into the bloodstream is not increased in the course of complex immune-mediated processes associated with AEDS. |
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Authors:
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Alicja Kasperska-Zajac; Barbara Rogala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inflammation Volume: 29 ISSN: 0360-3997 ISO Abbreviation: Inflammation Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2006-08-31 Completed Date: 2007-01-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7600105 Medline TA: Inflammation Country: United States |
Other Details:
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Languages: eng Pagination: 90-3 Citation Subset: IM |
Affiliation:
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Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland. kasperska@plusnet.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens / chemistry Case-Control Studies Dermatitis / blood* Dermatitis, Atopic / blood* Female Humans Immunoglobulin E / chemistry Inflammation Male Middle Aged Receptors, Cell Surface / blood* Receptors, Urokinase Plasminogen Activator Syndrome Urokinase-Type Plasminogen Activator / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/PLAUR protein, human; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; 37341-29-0/Immunoglobulin E; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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