| Circulating levels of relaxin and its relation to cardiovascular function in patients with hypertension. | |
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MedLine Citation:
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PMID: 19353414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The role of endogenous relaxin on hypertensive cardiovascular damage remains unknown. We investigated the relaxin level and its relation to cardiovascular function in patients with never treated hypertension (HT). METHODS: We studied 42 (47.8+/-10 years) never treated patients with HT and 40 age-matched (47+/-8.6 years) normotensive individuals. Serum relaxin levels were determined in all subjects using enzyme-linked immunosorbent assay. Left ventricular (LV) diameters were evaluated by transthoracic echocardiography. Ejection fraction and LV mass index were measured. Diastolic functions were evaluated with both conventional and tissue Doppler echocardiography. We evaluated central aortic pressures, heart rate-corrected augmentation index (AIx@75), a marker of wave reflections, and aortic pulse wave velocity (PWV) as indices of elastic-type aortic stiffness of the study population using applanation tonometry (SphygmoCor). RESULTS: Relaxin levels were significantly lower in hypertensive patients as compared with controls (36.5+/-7.3 vs 49.7+/-39.8 pg/ml, p=0.03). The relaxin level was negatively correlated with brachial and central aortic pressure. However, serum relaxin was not significantly associated with LV diameters, ejection fraction, LV mass index, LV diastolic function, AIx@75 or aortic PWV in our study. CONCLUSION: Serum relaxin is decreased in patients with HT. However, low endogenous relaxin is not related to cardiovascular function. |
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Authors:
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Omer Gedikli; Hulya Yilmaz; Abdulkadir Kiris; Kayhan Karaman; Serkan Ozturk; Merih Baykan; Utku Ucar; Ismet Durmus; Caner Karahan; Sukru Celik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure Volume: 18 ISSN: 1651-1999 ISO Abbreviation: Blood Press. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-08 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: Norway |
Other Details:
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Languages: eng Pagination: 68-73 Citation Subset: IM |
Affiliation:
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Department of Cardiology, KTU Faculty of Medicine, Trabzon, Turkey. omergedikli@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aorta / physiopathology Blood Pressure Case-Control Studies Compliance Enzyme-Linked Immunosorbent Assay Female Heart / physiopathology* Heart Function Tests Heart Ventricles / ultrasonography Hemodynamics* Humans Hypertension / blood*, physiopathology Male Middle Aged Organ Size Relaxin / blood*, physiology Risk Factors Stroke Volume |
| Chemical | |
Reg. No./Substance:
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9002-69-1/Relaxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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