Document Detail

Circulating levels of relaxin and its relation to cardiovascular function in patients with hypertension.
MedLine Citation:
PMID:  19353414     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of endogenous relaxin on hypertensive cardiovascular damage remains unknown. We investigated the relaxin level and its relation to cardiovascular function in patients with never treated hypertension (HT). METHODS: We studied 42 (47.8+/-10 years) never treated patients with HT and 40 age-matched (47+/-8.6 years) normotensive individuals. Serum relaxin levels were determined in all subjects using enzyme-linked immunosorbent assay. Left ventricular (LV) diameters were evaluated by transthoracic echocardiography. Ejection fraction and LV mass index were measured. Diastolic functions were evaluated with both conventional and tissue Doppler echocardiography. We evaluated central aortic pressures, heart rate-corrected augmentation index (AIx@75), a marker of wave reflections, and aortic pulse wave velocity (PWV) as indices of elastic-type aortic stiffness of the study population using applanation tonometry (SphygmoCor). RESULTS: Relaxin levels were significantly lower in hypertensive patients as compared with controls (36.5+/-7.3 vs 49.7+/-39.8 pg/ml, p=0.03). The relaxin level was negatively correlated with brachial and central aortic pressure. However, serum relaxin was not significantly associated with LV diameters, ejection fraction, LV mass index, LV diastolic function, AIx@75 or aortic PWV in our study. CONCLUSION: Serum relaxin is decreased in patients with HT. However, low endogenous relaxin is not related to cardiovascular function.
Omer Gedikli; Hulya Yilmaz; Abdulkadir Kiris; Kayhan Karaman; Serkan Ozturk; Merih Baykan; Utku Ucar; Ismet Durmus; Caner Karahan; Sukru Celik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  18     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-08     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Department of Cardiology, KTU Faculty of Medicine, Trabzon, Turkey.
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MeSH Terms
Aorta / physiopathology
Blood Pressure
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Heart / physiopathology*
Heart Function Tests
Heart Ventricles / ultrasonography
Hypertension / blood*,  physiopathology
Middle Aged
Organ Size
Relaxin / blood*,  physiology
Risk Factors
Stroke Volume
Reg. No./Substance:

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