Document Detail


Circulating levels of placental protein 14 and progesterone following Mifepristone (RU38486) and Gemeprost for termination of first trimester pregnancy.
MedLine Citation:
PMID:  2744189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten patients underwent successful termination of first trimester pregnancies with RU38486 (Mifepristone, Roussel Laboratories Ltd., Broadwater Park, Uxbridge, Middlesex, United Kingdom) followed 2 days later by a prostaglandin (Gemeprost, May and Baker Ltd., Dagenham, Essex, United Kingdom) pessary. Four hours after administration of RU38486, the levels of progesterone (P) started to fall and continued to show a gradual decline until the abortion was completed, when a steep fall to follicular phase values was observed. Levels of placental protein 14 remained unaltered until 2 days after RU38486 administration, when levels were increased. The rise in placental protein 14 in association with falling P concentrations suggests that the decidual secretion of placental protein 14 might be independent of P. Fertil Steril 52:66, 1989.
Mifepristone (RU38486) when used in conjunction with a vaginal prostaglandin acts as an efficient method of abortion for 1st trimester cases. Ten women were administered RU38486, a synthetic 19-norsteroid that binds to the progesterone (P) receptor. It is given orally and acts as an antagonist the effects of P on target cells. When used with a prostaglandin, Mifepristone has a 100% success rate in termination of an early pregnancy. All of the women were less than 9 weeks pregnant and had no complications. 48 hours after the Mifepristone was administered, the women returned to the hospital for the insertion of a vaginal pessary (Gemeprost, 1 mg). Until the abortion is finished, there is a fall in P levels following the administration of Mifepristone. All patients aborted successfully. No change in levels of placental protein 14 were observed until 48 hours later when levels rose. It is therefore submitted that the secretion of placental protein 14 by the decidua in early pregnancy is not dependent on P and that other factors must be involved.
Authors:
R J Howell; F Olajide; B Teisner; G Grudzinskas; T Chard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  52     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-14     Completed Date:  1989-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  66-8     Citation Subset:  IM; J    
Affiliation:
St. Bartholomew's Hospital Medical College, London Hospital Medical College, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / administration & dosage*
Abortifacient Agents, Steroidal / administration & dosage*
Abortion, Induced / methods*
Alprostadil / administration & dosage,  analogs & derivatives
Estrenes / administration & dosage
Female
Glycoproteins*
Humans
Mifepristone
Pregnancy
Pregnancy Proteins / blood*
Pregnancy Trimester, First
Progesterone / blood*
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Steroidal; 0/Estrenes; 0/Glycoproteins; 0/PAEP protein, human; 0/Pregnancy Proteins; 57-83-0/Progesterone; 64318-79-2/gemeprost; 745-65-3/Alprostadil; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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