Document Detail


Circulating levels of matrix metalloproteinase-9 and abdominal aortic pathology: from the Dallas Heart Study.
MedLine Citation:
PMID:  22002999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior reports have associated increased circulating levels of matrix metalloproteinase-9 (MMP-9), an endopeptidase active in the extracellular matrix, with the formation and rupture of aortic aneurysms, raising the possibility that MMP-9 may be a useful diagnostic or therapeutic target for aortic pathology. However, associations between MMP-9 and pathological abdominal aortic phenotypes in the general population have not been reported. In the Dallas Heart Study, a population-based sample of Dallas County residents (n = 2304), we measured MMP-9 and performed magnetic resonance imaging (MRI) of the abdominal aorta, measuring aortic compliance, plaque, wall thickness and luminal diameter. After adjustment for traditional cardiac risk factors and body size, higher MMP-9 quartiles were independently associated with higher aortic wall thickness and larger luminal diameter (p < 0.0001 for each), but not abdominal aortic plaque (p = 0.08), coronary artery calcium (p = 0.20) or the aortic luminal diameter/aortic wall thickness ratio (p = 0.37), supporting the hypothesis that therapies targeting MMP-9 may affect the abdominal aortic wall and modify aortic pathology.
Authors:
Justin L Grodin; Tiffany M Powell-Wiley; Colby R Ayers; Darpan S Kumar; Anand Rohatgi; Amit Khera; Darren K McGuire; James A de Lemos; Sandeep R Das
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  16     ISSN:  1477-0377     ISO Abbreviation:  Vasc Med     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-02-21     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Aorta, Abdominal / pathology*
Aortic Aneurysm, Abdominal / enzymology*,  ethnology,  pathology*
Cohort Studies
Cross-Sectional Studies
European Continental Ancestry Group
Female
Hispanic Americans
Humans
Magnetic Resonance Imaging
Male
Matrix Metalloproteinase 9 / blood*
Middle Aged
Plaque, Atherosclerotic / pathology*
Texas / ethnology
Vascular Calcification / pathology
Grant Support
ID/Acronym/Agency:
M01-RR00633/RR/NCRR NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.24.35/Matrix Metalloproteinase 9
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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