| Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages. | |
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MedLine Citation:
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PMID: 12456605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to investigate the changes in circulating levels and the clinical use of inhibin A, activin A and follistatin as endocrine markers of early pregnancy loss. METHODS: Blood samples were collected from women presenting with a sporadic missed miscarriage (n = 10), and controls having pregnancy termination at 8-12 weeks (n = 15) and from women with a history of unexplained recurrent miscarriages (n = 12) at 6-12 weeks gestation. All samples were assayed for inhibin A, inhibin B, activin A, follistatin, hCG, estradiol and progesterone. RESULTS: Serum inhibin A, hCG, estradiol and progesterone levels were significantly ( approximately 2-3 fold) decreased in sporadic miscarriages compared with controls. In the recurrent miscarriage group, time dependent changes in plasma inhibin A and hCG levels were significantly (P < 0.05) altered in the group that had a subsequent miscarriage compared with those who had a live birth. At 6-7 weeks gestation, plasma inhibin A ( approximately 4 fold, P < 0.01), hCG ( approximately 4 fold, P < 0.01) and estradiol ( approximately 2 fold, P < 0.001) levels were significantly lower in women who went on to have another miscarriage than those with a live birth. Inhibin B levels were near the detection limit of the assay. CONCLUSIONS: Our findings suggest that inhibin A is a specific marker of early pregnancy loss before the onset of the clinical symptoms of recurrent miscarriage. There is a high degree of association between levels of inhibin A and hCG in cases of miscarriage, indicating that these two proteins could be used in combination to predict future pregnancy outcome. |
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Authors:
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S Muttukrishna; E Jauniaux; N Greenwold; H McGarrigle; S Jivraj; S Carter; S Elgaddal; N Groome; L Regan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 17 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-28 Completed Date: 2003-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 3072-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Royal Free-UCL Medical School, 86-96 Chenies Mews, London WC1E 6HX, UK. s.muttukrishna@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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blood* Abortion, Missed / blood* Activins / blood* Adult Biological Markers / blood Chorionic Gonadotropin / blood Estradiol / blood Female Follistatin / blood* Gestational Age Humans Inhibin-beta Subunits / blood* Inhibins / blood* Longitudinal Studies Pregnancy Progesterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin; 0/Follistatin; 0/activin A; 0/inhibin A; 104625-48-1/Activins; 50-28-2/Estradiol; 57-83-0/Progesterone; 57285-09-3/Inhibins; 93443-12-0/Inhibin-beta Subunits |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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