Document Detail

Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages.
MedLine Citation:
PMID:  12456605     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to investigate the changes in circulating levels and the clinical use of inhibin A, activin A and follistatin as endocrine markers of early pregnancy loss. METHODS: Blood samples were collected from women presenting with a sporadic missed miscarriage (n = 10), and controls having pregnancy termination at 8-12 weeks (n = 15) and from women with a history of unexplained recurrent miscarriages (n = 12) at 6-12 weeks gestation. All samples were assayed for inhibin A, inhibin B, activin A, follistatin, hCG, estradiol and progesterone. RESULTS: Serum inhibin A, hCG, estradiol and progesterone levels were significantly ( approximately 2-3 fold) decreased in sporadic miscarriages compared with controls. In the recurrent miscarriage group, time dependent changes in plasma inhibin A and hCG levels were significantly (P < 0.05) altered in the group that had a subsequent miscarriage compared with those who had a live birth. At 6-7 weeks gestation, plasma inhibin A ( approximately 4 fold, P < 0.01), hCG ( approximately 4 fold, P < 0.01) and estradiol ( approximately 2 fold, P < 0.001) levels were significantly lower in women who went on to have another miscarriage than those with a live birth. Inhibin B levels were near the detection limit of the assay. CONCLUSIONS: Our findings suggest that inhibin A is a specific marker of early pregnancy loss before the onset of the clinical symptoms of recurrent miscarriage. There is a high degree of association between levels of inhibin A and hCG in cases of miscarriage, indicating that these two proteins could be used in combination to predict future pregnancy outcome.
S Muttukrishna; E Jauniaux; N Greenwold; H McGarrigle; S Jivraj; S Carter; S Elgaddal; N Groome; L Regan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  17     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-28     Completed Date:  2003-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  3072-8     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Royal Free-UCL Medical School, 86-96 Chenies Mews, London WC1E 6HX, UK.
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MeSH Terms
Abortion, Habitual / blood*
Abortion, Missed / blood*
Activins / blood*
Biological Markers / blood
Chorionic Gonadotropin / blood
Estradiol / blood
Follistatin / blood*
Gestational Age
Inhibin-beta Subunits / blood*
Inhibins / blood*
Longitudinal Studies
Progesterone / blood
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/Follistatin; 0/activin A; 0/inhibin A; 104625-48-1/Activins; 50-28-2/Estradiol; 57-83-0/Progesterone; 57285-09-3/Inhibins; 93443-12-0/Inhibin-beta Subunits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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