| Circulating levels of inflammatory markers in intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 20614004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B--probably reflecting brain and adipose tissue inflammation--in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation. Serum hs-CRP, PAI-1, and S100B levels were measured in 40 mothers, and their 20 AGA and 20 IUGR full-term fetuses and neonates on postnatal days 1 and 4. hs-CRP, PAI-1, and S100B levels did not differ at all time points between AGA and IUGR groups. We conclude that the lack of difference in hs-CRP, PAI-1 and S100B levels, between IUGR and AGA fetuses/neonates--despite the lower birth weight, reflecting reduced fat mass in the former--might indicate more intense adipose tissue and nervous system inflammation in IUGRs. However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g. preeclampsia), cannot be excluded. |
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Authors:
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Theodora Boutsikou; George Mastorakos; Marialena Kyriakakou; Alexandra Margeli; Demetrios Hassiakos; Ioannis Papassotiriou; Christina Kanaka-Gantenbein; Ariadne Malamitsi-Puchner |
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Publication Detail:
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Type: Journal Article Date: 2010-06-03 |
Journal Detail:
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Title: Mediators of inflammation Volume: 2010 ISSN: 1466-1861 ISO Abbreviation: Mediators Inflamm. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9209001 Medline TA: Mediators Inflamm Country: United States |
Other Details:
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Languages: eng Pagination: 790605 Citation Subset: IM |
Affiliation:
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Neonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood* C-Reactive Protein / metabolism Female Fetal Growth Retardation / blood*, immunology Humans Inflammation / blood* Nephelometry and Turbidimetry Nerve Growth Factors / blood Plasminogen Activator Inhibitor 1 / blood Pregnancy S100 Proteins / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nerve Growth Factors; 0/Plasminogen Activator Inhibitor 1; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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